Statins Decrease Oxidative Stress and ICD Therapies

Heather L Bloom; Irfan Shukrullah; Emir Veledar; Rebecca Gutmann; Barry London; Samuel C Dudley

doi:10.4061/2010/253803

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Statins Decrease Oxidative Stress and ICD Therapies

Journal article

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Peer reviewed

Statins Decrease Oxidative Stress and ICD Therapies

Heather L Bloom, Irfan Shukrullah, Emir Veledar, Rebecca Gutmann, Barry London and Samuel C Dudley

Cardiology research and practice, Vol.2010(1), pp.1-7

2010

DOI: 10.4061/2010/253803

PMCID: PMC2847377

PMID: 20369058

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Abstract

Recent studies demonstrate that statins decrease ventricular arrhythmias in internal cardioverter defibrillator (ICD) patients. The mechanism is unknown, but evidence links increased inflammatory and oxidative states with increased arrhythmias. We hypothesized that statin use decreases oxidation.Methods.304 subjects with ICDs were surveyed for ventricular arrhythmia. Blood was analyzed for derivatives of reactive oxygen species (DROMs) and interleukin-6 (IL-6).Results.Subjects included 252 (83%) men, 58% on statins, 20% had ventricular arrhythmias. Average age was 63 years and ejection fraction (EF) 20%. ICD implant duration was 29±27 months. Use of statins correlated with lower ICD events (r=0.12,P=.02). Subjects on statins had lower hsCRP (5.2 versus 6.3;P=.05) and DROM levels (373 versus 397;P=.03). Other factors, including IL-6 and EF did not differ between statin and nonstatin use, nor did beta-blocker or antiarrhythmic use. Multivariate cross-correlation analysis demonstrated that DROMs, statins, IL-6 and EF were strongly associated with ICD events. Multivariate regression shows DROMs to be the dominant predictor.Conclusion.ICD event rate correlates with DROMs, a measure of lipid peroxides. Use of statins is associated with reduced DROMs and fewer ICD events, suggesting that statins exert their effect through reducing oxidation.

Details

Title: Subtitle: Statins Decrease Oxidative Stress and ICD Therapies
Creators: Heather L Bloom - Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA, Division of Cardiology, Atlanta Veterans Administration Medical Center, Atlanta, GA 30033, USA
Irfan Shukrullah - Section of Cardiology, University of Illinois at Chicago, Chicago, IL 60612, USA
Emir Veledar - Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Rebecca Gutmann - University of Pittsburg Medical Center Presbyterian, Pittsburg, PA 15213, USA
Barry London - University of Pittsburg Medical Center Presbyterian, Pittsburg, PA 15213, USA
Samuel C Dudley - Section of Cardiology, University of Illinois at Chicago, Chicago, IL 60612, USA
Resource Type: Journal article
Publication Details: Cardiology research and practice, Vol.2010(1), pp.1-7
DOI: 10.4061/2010/253803
PMID: 20369058
PMCID: PMC2847377
NLM abbreviation: Cardiol Res Pract
ISSN: 2090-0597
eISSN: 2090-0597
Language: English
Date published: 2010
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984025690002771

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