Statins, angiotensin-converting enzyme inhibitors, and physical performance in older women

Shelly L Gray; Aaron K Aragaki; Michael J LaMonte; Barbara B Cochrane; Charles Kooperberg; Jennifer G Robinson; Nancy F Woods; Andrea Z LaCroix

doi:10.1111/jgs.12029

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Statins, angiotensin-converting enzyme inhibitors, and physical performance in older women

Journal article

Open access

Statins, angiotensin-converting enzyme inhibitors, and physical performance in older women

Shelly L Gray, Aaron K Aragaki, Michael J LaMonte, Barbara B Cochrane, Charles Kooperberg, Jennifer G Robinson, Nancy F Woods and Andrea Z LaCroix

Journal of the American Geriatrics Society (JAGS), Vol.60(12), pp.2206-2214

12/2012

DOI: 10.1111/jgs.12029

PMCID: PMC3521070

PMID: 23176078

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https://www.ncbi.nlm.nih.gov/pmc/articles/3521070View

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Abstract

To examine associations between angiotensin-converting enzyme (ACE) inhibitor and statin medications and baseline and mean annual change in physical performance measures and muscle strength in older women. Prospective cohort study. Participants from the Women's Health Initiative Clinical Trials aged 65 to 79 at baseline who had physical performance measures, self-report of health insurance, and no prior history of stroke or congestive heart failure were included (N = 5,777). Women were recruited between 1993 and 1998. Medication use was ascertained through a baseline inventory. Physical performance measures (timed 6-m walk, repeated chair stands in 15 seconds) and grip strength were assessed at baseline and follow-up Years 1, 3, and 6. Multivariable-adjusted linear repeated-measures models were adjusted for demographic and health characteristics. ACE inhibitor use was associated with lower mean grip strength at baseline (22.40 kg, 95% confidence interval (CI) = 21.89-22.91 vs 23.18 kg, 95% CI 23.02-23.34; P = .005) and greater mean annual change in number of chair stands (-0.182, 95% CI -0.217 to -0.147 vs -0.145, 95% CI -0.156 to -0.133; P = .05) than nonuse. Statin use was not significantly associated with baseline measures or mean annual change for any outcome. A subgroup analysis suggested that statin use was associated with less mean annual change in chair stands (P = .006) in the oldest women. These results do not support an association between statin or ACE inhibitor use and slower decline in physical performance or muscle strength and thus do not support the use of these medications for preserving functional status in older adults.

Walking

Angiotensin-Converting Enzyme Inhibitors - therapeutic use

Gait

Humans

Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use

Female

Physical Fitness

Aged

Muscle Strength - drug effects

Hand Strength

Details

Title: Subtitle: Statins, angiotensin-converting enzyme inhibitors, and physical performance in older women
Creators: Shelly L Gray - School of Pharmacy, University of Washington, Seattle, Washington 98195, USA. slgray@u.washington.edu
Aaron K Aragaki
Michael J LaMonte
Barbara B Cochrane
Charles Kooperberg
Jennifer G Robinson
Nancy F Woods
Andrea Z LaCroix
Resource Type: Journal article
Publication Details: Journal of the American Geriatrics Society (JAGS), Vol.60(12), pp.2206-2214
DOI: 10.1111/jgs.12029
PMID: 23176078
PMCID: PMC3521070
NLM abbreviation: J Am Geriatr Soc
ISSN: 0002-8614
eISSN: 1532-5415
Publisher: United States
Grant note: HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100046C / PHS HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS P30 CA015704 / NCI NIH HHS R01 AG025441 / NIA NIH HHS HHSN271201100004C / PHS HHS HHSN268201100003C / PHS HHS HHSN268201100004C / WHI NIH HHS HHSN268201100046C / NHLBI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS HHSN268201100004C / PHS HHS HHSN268201100002C / PHS HHS HHSN268201100003C / WHI NIH HHS HHSN268201100001C / PHS HHS
Language: English
Date published: 12/2012
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995171202771

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