Status Epilepticus–Induced Hyperemia and Brain Tissue Hypoxia After Cardiac Arrest

Sang-Bae KO; Santiago ORTEGA-GUTIERREZ; H. Alex CHOI; Jan CLAASSEN; Mary PRESCIUTTI; J. Michael SCHMIDT; Neeraj BADJATIA; Kiwon LEE; Stephan A MAYER

doi:10.1001/archneurol.2011.240

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Status Epilepticus–Induced Hyperemia and Brain Tissue Hypoxia After Cardiac Arrest

Journal article

Open access

Peer reviewed

Status Epilepticus–Induced Hyperemia and Brain Tissue Hypoxia After Cardiac Arrest

Sang-Bae KO, Santiago ORTEGA-GUTIERREZ, H. Alex CHOI, Jan CLAASSEN, Mary PRESCIUTTI, J. Michael SCHMIDT, Neeraj BADJATIA, Kiwon LEE and Stephan A MAYER

Archives of neurology (Chicago), Vol.68(10), pp.1323-1326

2011

DOI: 10.1001/archneurol.2011.240

PMID: 21987548

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Abstract

Objective: To report changes of cerebral blood flow and metabolism associated with status epilepticus after cardiac arrest. Design: Case report. Setting: Neurological intensive care unit in a university hospital. Patient: An 85-year-old man resuscitated from out-of-hospital cardiac arrest underwent brain multimodality monitoring and treatment with therapeutic hypothermia. Main outcome measures: Changes of cerebral blood flow and metabolism. Results: Repetitive electrographic seizure activity detected at the start of monitoring was associated with dramatic reductions in brain tissue oxygen tension and striking surges in cerebral blood flow and brain temperature. Intravenous lorazepam and levetiracetam administration resulted in immediate cessation of the seizures and these associated derangements. The lactate to pyruvate ratio was initially elevated and trended down after administration of anticonvulsants. Conclusion: Brain multimodality monitoring is a feasible method for evaluating secondary brain injury associated with seizure activity after cardiac arrest.

Neurology

Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy

Biological and medical sciences

Medical sciences

Nervous system (semeiology, syndromes)

Details

Title: Subtitle: Status Epilepticus–Induced Hyperemia and Brain Tissue Hypoxia After Cardiac Arrest
Creators: Sang-Bae KO - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
Santiago ORTEGA-GUTIERREZ - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
H. Alex CHOI - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
Jan CLAASSEN - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
Mary PRESCIUTTI - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
J. Michael SCHMIDT - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
Neeraj BADJATIA - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
Kiwon LEE - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
Stephan A MAYER - Neurological Intensive Care Unit, Columbia University College of Physicians and Surgeons, New York, New York, United States
Resource Type: Journal article
Publication Details: Archives of neurology (Chicago), Vol.68(10), pp.1323-1326
DOI: 10.1001/archneurol.2011.240
PMID: 21987548
NLM abbreviation: Arch Neurol
ISSN: 0003-9942
eISSN: 1538-3687
Publisher: American Medical Association; Chicago, IL
Language: English
Date published: 2011
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020503202771

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