Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein

Jun Zeng; Yuwen Zhang; Jiaqing Hao; Yanwen Sun; Shujun Liu; David A Bernlohr; Edward R Sauter; Margot P Cleary; Jill Suttles; Bing Li

doi:10.4049/jimmunol.1701416

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Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein

Journal article

Peer reviewed

Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein

Jun Zeng, Yuwen Zhang, Jiaqing Hao, Yanwen Sun, Shujun Liu, David A Bernlohr, Edward R Sauter, Margot P Cleary, Jill Suttles and Bing Li

The Journal of immunology (1950), Vol.200(10), pp.3407-3419

05/15/2018

DOI: 10.4049/jimmunol.1701416

PMCID: PMC5940522

PMID: 29626089

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Abstract

Obesity is associated with elevated levels of free fatty acids (FAs) and proinflammatory CD11c macrophages. However, whether and how free FAs contribute to CD11c macrophage differentiation and proinflammatory functions remain unclear. Here we report that dietary saturated FAs, but not unsaturated FAs, promoted the differentiation and function of CD11c macrophages. Specifically, we demonstrated that stearic acid (SA) significantly induced CD11c expression in monocytes through activation of the nuclear retinoid acid receptor. More importantly, cytosolic expression of epidermal FA binding protein (E-FABP) in monocytes/macrophages was shown to be critical to the mediation of the SA-induced effect. Depletion of E-FABP not only inhibited SA-induced CD11c upregulation in macrophages in vitro but also abrogated high-saturated-fat diet-induced skin lesions in obese mouse models in vivo. Altogether, our data demonstrate a novel mechanism by which saturated FAs promote obesity-associated inflammation through inducing E-FABP/retinoid acid receptor-mediated differentiation of CD11c macrophages.

Animals

CD11c Antigen - metabolism

Fatty Acid-Binding Proteins - metabolism

Fatty Acids - metabolism

Inflammation - metabolism

Macrophages - drug effects

Macrophages - metabolism

Mice

Mice, Inbred C57BL

Mice, Obese

Monocytes - drug effects

Monocytes - metabolism

Obesity - metabolism

Stearic Acids - pharmacology

Up-Regulation - drug effects

Details

Title: Subtitle: Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein
Creators: Jun Zeng - University of Louisville
Yuwen Zhang - University of Louisville
Jiaqing Hao - University of Louisville
Yanwen Sun - University of Louisville
Shujun Liu - University of Minnesota
David A Bernlohr - University of Minnesota
Edward R Sauter - Hartford Hospital
Margot P Cleary - University of Minnesota
Jill Suttles - University of Louisville
Bing Li - University of Louisville
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.200(10), pp.3407-3419
DOI: 10.4049/jimmunol.1701416
PMID: 29626089
PMCID: PMC5940522
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Grant note: R01 CA180986 / NCI NIH HHS R01 CA177679 / NCI NIH HHS R01 DK053189 / NIDDK NIH HHS
Language: English
Date published: 05/15/2018
Academic Unit: Pathology; Surgery
Record Identifier: 9984696542202771

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