Journal article
Stem Cell Therapy Remediates Reconstruction of the Craniofacial Skeleton After Radiation Therapy
Stem cells and development, Vol.22(11), pp.1625-1632
06/01/2013
DOI: 10.1089/scd.2012.0472
PMCID: PMC3657278
PMID: 23282102
Abstract
This study utilized transplanted bone marrow stromal cells (BMSCs) as a cellular replacement therapy to remedy radiation-induced injury and restore impaired new bone formation during distraction osteogenesis (DO). BMSC therapy brought about the successful generation of new bone and significantly improved both the rate and quality of a bony union of irradiated, distracted [X-ray radiation therapy (XRT)/DO] murine mandibles to the level of nonirradiated DO animals. The bone mineral density and bone volume fraction were also significantly improved by the BMSC replacement therapy showing no difference when compared to nonirradiated animals. Finally, a biomechanical analysis examining the yield, failure load, and ultimate load also demonstrated a significantly improved structural integrity in BMSC-treated XRT/DO mandibles over XRT/DO alone. These results indicate that administration of BMSCs intraoperatively to a radiated distraction gap can function as an adequate stimulant to rescue the ability for irradiated bone to undergo DO and produce a healed regenerate of a vastly superior quality and strength. We believe that the fundamental information on the optimization of bone regeneration in the irradiated mandible provided by this work has immense potential to be translated from the bench to the bedside to lead to improved therapeutic options for patients suffering from the disastrous sequelae of radiation therapy.
Details
- Title: Subtitle
- Stem Cell Therapy Remediates Reconstruction of the Craniofacial Skeleton After Radiation Therapy
- Creators
- Sagar S. Deshpande - University of MichiganKathleen K. Gallagher - University of MichiganAlexis Donneys - Plastic Surgery HospitalCatherine N. Tchanque-Fossuo - University of MichiganDeniz Sarhaddi - University of MichiganHongli Sun - University of MichiganPaul H. Krebsbach - Biomedical Engineering - Medical SchoolSteven R. Buchman - Neurosurgery
- Resource Type
- Journal article
- Publication Details
- Stem cells and development, Vol.22(11), pp.1625-1632
- DOI
- 10.1089/scd.2012.0472
- PMID
- 23282102
- PMCID
- PMC3657278
- NLM abbreviation
- Stem Cells Dev
- ISSN
- 1547-3287
- eISSN
- 1557-8534
- Publisher
- Mary Ann Liebert, Inc
- Number of pages
- 8
- Grant note
- R01CA125187 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 06/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery
- Record Identifier
- 9984367740102771
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