Journal article
Stem and endothelial progenitor cells in erection biology
International journal of impotence research, Vol.20(3), pp.243-254
2008
DOI: 10.1038/sj.ijir.3901635
PMID: 18256677
Abstract
Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an erection for satisfactory sexual relations. The past 20 years of basic science research on erection physiology has been devoted to investigating the pathogenesis of ED and has led to the conclusion that ED is predominately a disease of vascular origin with dramatic changes occurring in the endothelium. Research has also led to an understanding of the biochemical factors and intracellular mechanisms responsible for corporal smooth muscle contraction and relaxation and the influence of endothelium-derived relaxing factors. The development of methods to deliver both stem and endothelial cells to the penis has kindled a keen interest in treating ED with gene- and cell-based therapies. In this paper, erection physiology and stem cell biology is reviewed, and the potential application of novel cell-based therapies for the treatment of ED is discussed.
Details
- Title: Subtitle
- Stem and endothelial progenitor cells in erection biology
- Creators
- T. D STRONG - Department of Urology, The Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, United StatesM. A GEBSKA - Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, United StatesH. C CHAMPION - Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, United StatesA. L BURNETT - Department of Urology, The Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, United StatesT. J BIVALACQUA - Department of Urology, The Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- International journal of impotence research, Vol.20(3), pp.243-254
- DOI
- 10.1038/sj.ijir.3901635
- PMID
- 18256677
- NLM abbreviation
- Int J Impot Res
- ISSN
- 0955-9930
- eISSN
- 1476-5489
- Publisher
- Nature Publishing
- Language
- English
- Date published
- 2008
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094718802771
Metrics
25 Record Views