Journal article
Stem cells and lung regeneration
American Journal of Physiology: Cell Physiology, Vol.319(4), pp.C675-C693
10/01/2020
DOI: 10.1152/ajpcell.00036.2020
PMCID: PMC7654650
PMID: 32783658
Abstract
The ability to replace defective cells in an airway with cells that can engraft, integrate, and restore a functional epithelium could potentially cure a number of lung diseases. Progress toward the development of strategies to regenerate the adult lung by either in vivo or ex vivo targeting of endogenous stem cells or pluripotent stem cell derivatives is limited by our fundamental lack of understanding of the mechanisms controlling human lung development, the precise identity and function of human lung stem and progenitor cell types, and the genetic and epigenetic control of human lung fate. In this review, we intend to discuss the known stem/progenitor cell populations, their relative differences between rodents and humans, their roles in chronic lung disease, and their therapeutic prospects. Additionally, we highlight the recent breakthroughs that have increased our understanding of these cell types. These advancements include novel lineage-traced animal models and single-cell RNA sequencing of human airway cells, which have provided critical information on the stem cell subtypes, transition states, identifying cell markers, and intricate pathways that commit a stem cell to differentiate or to maintain plasticity. As our capacity to model the human lung evolves, so will our understanding of lung regeneration and our ability to target endogenous stem cells as a therapeutic approach for lung disease.
Details
- Title: Subtitle
- Stem cells and lung regeneration
- Creators
- Kalpaj R Parekh - University of IowaJanna Nawroth - Hastings CenterAlbert Pai - University of IowaShana M Busch - Hastings CenterChristiana N Senger - Hastings CenterAmy L Ryan - Hastings Center
- Resource Type
- Journal article
- Publication Details
- American Journal of Physiology: Cell Physiology, Vol.319(4), pp.C675-C693
- DOI
- 10.1152/ajpcell.00036.2020
- PMID
- 32783658
- PMCID
- PMC7654650
- ISSN
- 0363-6143
- eISSN
- 1522-1563
- Grant note
- P30 DK054759 / NIDDK NIH HHS R01 HL139828 / NHLBI NIH HHS R01 HL136370 / NHLBI NIH HHS 5R01-HL139828-03 / HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
- Language
- English
- Date published
- 10/01/2020
- Academic Unit
- Anatomy and Cell Biology; Cardiothoracic Surgery
- Record Identifier
- 9984284332502771
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