Stem cells and their niches: integrated units that maintain Drosophila tissues

A C Spradling; T Nystul; D Lighthouse; L Morris; D Fox; R Cox; T Tootle; R Frederick; A Skora

doi:10.1101/sqb.2008.73.023

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Stem cells and their niches: integrated units that maintain Drosophila tissues

Journal article

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Stem cells and their niches: integrated units that maintain Drosophila tissues

A C Spradling, T Nystul, D Lighthouse, L Morris, D Fox, R Cox, T Tootle, R Frederick and A Skora

Cold Spring Harbor Symposia on Quantitative Biology, Vol.73, pp.49-57

2008

DOI: 10.1101/sqb.2008.73.023

PMID: 19022764

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Abstract

The genetic analysis of four distinct Drosophila stem cells and their niches has revealed principles of stem cell biology that are likely to apply widely. A stem cell and its niche act together as integral parts of a system that supplies replacement cells when and where they are needed within a tissue. Stem cell/niche units are highly regulated and continue to operate despite the periodic turnover and replacement of all of their component cells. To successfully respond to tissue needs, these units receive and process a wide range of local and systemic information. A stem cell alone would be no more use at this task than an isolated neuron. It is only when integrated into a system of multiple interacting cells (the niche) that stem cells achieve the capacity to serve as the fundamental units of tissue homeostasis and repair.

Signal Transduction

Systems Biology

Adult Stem Cells - physiology

Adult Stem Cells - cytology

Animals, Genetically Modified

Organelles - physiology

Homeostasis

Receptors, Notch - physiology

Drosophila - cytology

Male

Germ Cells - physiology

Drosophila - physiology

Drosophila Proteins - physiology

Animals

Female

Germ Cells - cytology

Drosophila - genetics

Details

Title: Subtitle: Stem cells and their niches: integrated units that maintain Drosophila tissues
Creators: A C Spradling - Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, USA
T Nystul
D Lighthouse
L Morris
D Fox
R Cox
T Tootle
R Frederick
A Skora
Resource Type: Journal article
Publication Details: Cold Spring Harbor Symposia on Quantitative Biology, Vol.73, pp.49-57
DOI: 10.1101/sqb.2008.73.023
PMID: 19022764
NLM abbreviation: Cold Spring Harb Symp Quant Biol
ISSN: 0091-7451
eISSN: 1943-4456
Publisher: United States
Grant note: Howard Hughes Medical Institute F32 CA119676 / NCI NIH HHS
Language: English
Date published: 2008
Academic Unit: Anatomy and Cell Biology
Record Identifier: 9984025317302771

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