Stent-associated Symptoms After Two-stage Ureteroscopy: Results From STENTS

Daniel Garrett Wong; Jonathan D Harper; Naim M Maalouf; Joel Vetter; Hussein R Al-Khalidi; H Henry Lai; Brett A Johnson; Charles D Scales; Ziya Kirkali; Alana C Desai; USDRN Investigators

doi:10.1016/j.urology.2025.11.228

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Stent-associated Symptoms After Two-stage Ureteroscopy: Results From STENTS

Journal article

Peer reviewed

Stent-associated Symptoms After Two-stage Ureteroscopy: Results From STENTS

Daniel Garrett Wong, Jonathan D Harper, Naim M Maalouf, Joel Vetter, Hussein R Al-Khalidi, H Henry Lai, Brett A Johnson, Charles D Scales, Ziya Kirkali, Alana C Desai, …

Urology (Ridgewood, N.J.), Vol.209, pp.25-29

03/01/2026

DOI: 10.1016/j.urology.2025.11.228

PMID: 41237969

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Abstract

To compare patient-reported stent-associated symptoms (SAS) after first- and second-stage unilateral ureteroscopy with ureteral stent placement for treatment of urinary stones. Participants enrolled in the Study to Enhance Understanding of Stent-Associated Symptoms (STENTS) underwent unilateral URS with a ureteral stent for urinary stones and completed patient-reported outcome measures to assess SAS. Differences in pain intensity were evaluated at baseline and following first- and second-stage URS procedures. A propensity score-matched cohort of participants who underwent single-stage URS was compared to participants undergoing a two-staged procedure. Of the 424 participants who underwent unilateral URS, 40 (9.4%) had an unplanned staged procedure. Most participants (75%) undergoing a staged procedure had a narrow ureter or stricture. The median time to the second procedure was 14.0 days, with the second procedure mean operative time 25 min greater than the first stage. Preoperative pain intensity was similar before both procedures, whereas postoperative pain was lower after the second procedure compared to the first. In the matched cohort, patients reported comparable pain on POD 1, but lower pain scores in the two-stage group on PODs 3 and 5. Urinary symptoms were improved on PODs 1 and 3 after the second procedure compared to the first stage. Despite a longer procedure time, pain intensity appears to be lower after a second-stage procedure compared to the first. These results may be useful in counseling patients who require staged treatment.

Adult

Aged

Female

Humans

Male

Middle Aged

Patient Reported Outcome Measures

Postoperative Pain - diagnosis

Postoperative Pain - epidemiology

Postoperative Pain - etiology

Stents - adverse effects

Ureteral Calculi - surgery

Ureteroscopy - adverse effects

Ureteroscopy - methods

Details

Title: Subtitle: Stent-associated Symptoms After Two-stage Ureteroscopy: Results From STENTS
Creators: Daniel Garrett Wong - Washington University in St. Louis
Jonathan D Harper - University of Washington
Naim M Maalouf - The University of Texas Southwestern Medical Center
Joel Vetter - Washington University in St. Louis
Hussein R Al-Khalidi - Duke University
H Henry Lai - Washington University in St. Louis
Brett A Johnson - The University of Texas Southwestern Medical Center
Charles D Scales - Duke University
Ziya Kirkali - National Institute of Diabetes and Digestive and Kidney Diseases
Alana C Desai - Washington University in St. Louis
USDRN Investigators
Resource Type: Journal article
Publication Details: Urology (Ridgewood, N.J.), Vol.209, pp.25-29
DOI: 10.1016/j.urology.2025.11.228
PMID: 41237969
NLM abbreviation: Urology
ISSN: 0090-4295
eISSN: 1527-9995
Grant note: U24 DK110988 / NIDDK NIH HHS U01 DK110994 / NIDDK NIH HHS U01 DK110954 / NIDDK NIH HHS U01 DK110961 / NIDDK NIH HHS U01 DK110986 / NIDDK NIH HHS U01 DK110988 / NIDDK NIH HHS
Language: English
Date published: 03/01/2026
Academic Unit: Urology
Record Identifier: 9985244664902771

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