Stenting versus medical therapy alone for symptomatic intracranial arterial stenosis: protocol for a systematic review and individual patient data meta-analysis

Tao Wang; Zixuan Xing; Haozhi Gong; Colin P Derdeyn; Osama O Zaidat; Eyad Almallouhi; Jichang Luo; Peng Gao; Haibo Wang; Liqun Jiao

doi:10.1136/bmjopen-2023-071668

Back

Stenting versus medical therapy alone for symptomatic intracranial arterial stenosis: protocol for a systematic review and individual patient data meta-analysis

Journal article

Open access

Peer reviewed

Stenting versus medical therapy alone for symptomatic intracranial arterial stenosis: protocol for a systematic review and individual patient data meta-analysis

Tao Wang, Zixuan Xing, Haozhi Gong, Colin P Derdeyn, Osama O Zaidat, Eyad Almallouhi, Jichang Luo, Peng Gao, Haibo Wang and Liqun Jiao

BMJ open, Vol.13(6), e071668

06/20/2023

DOI: 10.1136/bmjopen-2023-071668

PMCID: PMC10314494

PMID: 37339837

Files and links (1)

url

https://doi.org/10.1136/bmjopen-2023-071668View

Published (Version of record) Open Access

Abstract

Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke worldwide. However, whether the treatment options for symptomatic ICAS is stent placement or medical therapy alone is still controversial. At present, three multicentre randomised controlled trials (RCTs) have been published, but their research designs are also slightly different and the conclusions are not completely consistent. Therefore, we plan to conduct a systematic review and individual patient data (IPD) meta-analysis of randomised clinical trials to ascertain safety and efficacy of stenting versus medical therapy alone for symptomatic patients with intracranial arterial stenosis. We will identify RCTs comparing stenting vs medical therapy alone in patients with symptomatic ICAS stenosis (70%-99%) through a systematic search, mainly including PubMed, MEDLINE, EMBASE, the Cochrane Library and ClinicalTrials.gov. Individual-level patient data for a prespecified list of variables will be sought from authors of all eligible studies. The primary outcome was a composite of stroke or death within 30 days, or stroke in territory of qualifying artery beyond 30 days after randomisation. IPD meta-analysis will be conducted with a one-stage approach. Ethical approval and individual patient consent will not be required in most cases since this IPD meta-analysis will use pseudoanonymised data from RCTs. Results will be disseminated through peer-reviewed journals and international conferences. CRD42022369922.

Arteries

Constriction, Pathologic - therapy

Endovascular Procedures - methods

Humans

Meta-Analysis as Topic

Stents - adverse effects

Stroke - etiology

Systematic Reviews as Topic

Details

Title: Subtitle: Stenting versus medical therapy alone for symptomatic intracranial arterial stenosis: protocol for a systematic review and individual patient data meta-analysis
Creators: Tao Wang - Capital Medical University
Zixuan Xing - Xi'an Jiaotong University
Haozhi Gong - Capital Medical University
Colin P Derdeyn - University of Iowa
Osama O Zaidat - St. Vincent Hospital
Eyad Almallouhi - Medical University of South Carolina
Jichang Luo - Capital Medical University
Peng Gao - Capital Medical University
Haibo Wang - Peking University First Hospital
Liqun Jiao - Capital Medical University
Resource Type: Journal article
Publication Details: BMJ open, Vol.13(6), e071668
DOI: 10.1136/bmjopen-2023-071668
PMID: 37339837
PMCID: PMC10314494
NLM abbreviation: BMJ Open
ISSN: 2044-6055
eISSN: 2044-6055
Grant note: name: Incubating Program of Capital Medical University, award: PYZ22041; name: Beijing Hospitals Authority’s Ascent Plan, award: DFL20220702
Language: English
Date published: 06/20/2023
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984437660202771

Metrics

7 Record Views

2 Times Cited - Web of Science