Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance

Christopher A Mela; Carrie Patterson; William K Thompson; Francis Papay; Yang Liu

doi:10.1371/journal.pone.0141956

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Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance

Journal article

Open access

Peer reviewed

Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance

Christopher A Mela, Carrie Patterson, William K Thompson, Francis Papay and Yang Liu

PloS one, Vol.10(11), pp.e0141956-e0141956

2015

DOI: 10.1371/journal.pone.0141956

PMCID: PMC4631490

PMID: 26529249

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https://doi.org/10.1371/journal.pone.0141956View

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Abstract

We have developed novel stereoscopic wearable multimodal intraoperative imaging and display systems entitled Integrated Imaging Goggles for guiding surgeries. The prototype systems offer real time stereoscopic fluorescence imaging and color reflectance imaging capacity, along with in vivo handheld microscopy and ultrasound imaging. With the Integrated Imaging Goggle, both wide-field fluorescence imaging and in vivo microscopy are provided. The real time ultrasound images can also be presented in the goggle display. Furthermore, real time goggle-to-goggle stereoscopic video sharing is demonstrated, which can greatly facilitate telemedicine. In this paper, the prototype systems are described, characterized and tested in surgeries in biological tissues ex vivo. We have found that the system can detect fluorescent targets with as low as 60 nM indocyanine green and can resolve structures down to 0.25 mm with large FOV stereoscopic imaging. The system has successfully guided simulated cancer surgeries in chicken. The Integrated Imaging Goggle is novel in 4 aspects: it is (a) the first wearable stereoscopic wide-field intraoperative fluorescence imaging and display system, (b) the first wearable system offering both large FOV and microscopic imaging simultaneously,

Animals

Chickens

Depth Perception

Humans

Image Processing, Computer-Assisted - instrumentation

Image Processing, Computer-Assisted - methods

Neoplasms - surgery

Neoplasms - veterinary

Poultry Diseases - surgery

Surgery, Computer-Assisted - instrumentation

Surgery, Computer-Assisted - methods

Telemedicine - instrumentation

Telemedicine - methods

Details

Title: Subtitle: Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance
Creators: Christopher A Mela - University of Akron
Carrie Patterson - University of Akron
William K Thompson - Glenn Research Center
Francis Papay - Cleveland Clinic
Yang Liu - University of Akron
Resource Type: Journal article
Publication Details: PloS one, Vol.10(11), pp.e0141956-e0141956
DOI: 10.1371/journal.pone.0141956
PMID: 26529249
PMCID: PMC4631490
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Language: English
Date published: 2015
Academic Unit: Electrical and Computer Engineering
Record Identifier: 9984197186002771

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