Journal article
Stereoselective S-nitrosocysteine recognition sites in rat brain
European journal of pharmacology, Vol.312(2), pp.R3-R5
1996
DOI: 10.1016/0014-2999(96)00607-3
PMID: 8894607
Abstract
We examined the effects of intracisternal (i.c.) injections (10–250 nmol) of the
l- and
d-isomers of
S-nitrosocysteine (
l- and
d-
S-nitrosocysteine) on the mean arterial blood pressure and heart rate of conscious rats, and the decomposition of
l- and
d-
S-nitrosocysteine to nitric oxide (NO) upon addition to brain homogenates. The i.c. injection of
l-
S-nitrosocysteine produced initial falls in mean arterial blood pressure and heart rate which were followed by increases in these parameters. The i.c. injection of
d-
S-nitrosocysteine did not produce initial falls in mean arterial blood pressure or heart rate but produced the subsequent increases in these parameters.
l- and
d-
S-nitrosocysteine decomposed equally to NO. These results suggest that the initial effects of
l-
S-nitrosocysteine may be due to the activation of stereoselective recognition sites on brain neurons.
Details
- Title: Subtitle
- Stereoselective S-nitrosocysteine recognition sites in rat brain
- Creators
- Stephen J Lewis - Department of Pharmacology and Cardiovascular Center, University of Iowa, Iowa City, IA 52242, USAMark D Travis - Department of Pharmacology and Cardiovascular Center, University of Iowa, Iowa City, IA 52242, USAJames N Bates - Department of Anesthesia and Cardiovascular Center, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.312(2), pp.R3-R5
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0014-2999(96)00607-3
- PMID
- 8894607
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 1996
- Academic Unit
- Anesthesia
- Record Identifier
- 9984007193302771
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