Stereotactic Atlas-Based Depth Electrode Localization in the Human Amygdala

Hiroyuki Oya; Hiroto Kawasaki; Nader S Dahdaleh; John A Wemmie; Matthew A Howard

doi:10.1159/000225975

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Stereotactic Atlas-Based Depth Electrode Localization in the Human Amygdala

Journal article

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Stereotactic Atlas-Based Depth Electrode Localization in the Human Amygdala

Hiroyuki Oya, Hiroto Kawasaki, Nader S Dahdaleh, John A Wemmie and Matthew A Howard

Stereotactic and functional neurosurgery, Vol.87(4), pp.219-228

08/2009

DOI: 10.1159/000225975

PMCID: PMC2790801

PMID: 19556831

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Abstract

Background: The efficacy of stereotactic neurosurgery procedures is critically dependent on the accuracy of the device placement procedure. The first step in this process involves correctly identifying the target location in three-dimensional brain space. In some clinical applications, this targeting process cannot be accomplished using MRI images of gross anatomical structures alone. The amygdala complex is a case in point, in that it consists of multiple histologically defined subnuclei with different functional characteristics. Methods: In this report, we describe an elastic atlas brain-morphing method that projects amygdala subnuclear anatomical information onto the MRI volumes of individual subjects. Results: The accuracy of this method was tested in 5 representative subjects using quantitative image-matching analytical techniques. The results demonstrate a high degree of intersubject variability in medial temporal lobe anatomy, and markedly superior anatomical matching performance by the elastic morphing method compared to Affine transformation. Conclusion: Nonlinear elastic morphing technique provides superior performance on fitting atlas templates to individual brain. The strengths and limitations of this and other atlas morphing methods are discussed in the context of emerging functional neurosurgery applications.

Laboratory Investigation

Details

Title: Subtitle: Stereotactic Atlas-Based Depth Electrode Localization in the Human Amygdala
Creators: Hiroyuki Oya - Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
Hiroto Kawasaki - Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
Nader S Dahdaleh - Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
John A Wemmie - Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
Matthew A Howard - Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: Stereotactic and functional neurosurgery, Vol.87(4), pp.219-228
DOI: 10.1159/000225975
PMID: 19556831
PMCID: PMC2790801
NLM abbreviation: Stereotact Funct Neurosurg
ISSN: 1011-6125
eISSN: 1423-0372
Publisher: S. Karger AG
Language: English
Date published: 08/2009
Academic Unit: Neurology; Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984003469602771

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