Journal article
Stereotactic body radiation therapy for low and intermediate risk prostate cancer—Results from a multi-institutional clinical trial
European Journal of Cancer, Vol.59, pp.142-151
05/2016
DOI: 10.1016/j.ejca.2016.02.014
PMID: 27035363
Abstract
We report the outcome of a phase I/II clinical trial of stereotactic body radiation therapy (SBRT) for low (LR) and select intermediate risk (IR) prostate cancer (PCa) patients. Eligible patients included men with prostate adenocarcinoma with Gleason score 6 with PSA ≤ 20 or Gleason 7 with PSA ≤ 15 and clinical stage ≤ T2b. For the phase I portion of the study patients in cohorts of 15 received 45, 47.5, or 50 Gray (Gy) in five fractions. Since the maximally tolerated dose was not met in the phase I study, an additional 47 patients received 50 Gy in five fractions in the phase II study. Toxicity using Common Toxicity Criteria for Adverse Events v. 3.0, quality of life, and outcome data was collected. A total of 91 patients are included for analysis; 63.7% had NCCN IR and 36.3% had LR PCa. At a median follow up of 54 months the actuarial freedom from biochemical failure was 100% at 3 years and 98.6% at 5 years. Actuarial distant metastasis free survival was 100% at 3 and 5 years. Overall survival was 94% at 3 years and 89.7% at 5 years with no deaths attributed to PCa. Acute and late urinary grade ≥ III toxicity occurred in 0% and 5.5% of patients, respectively. Gastrointestinal (GI) acute and late toxicity of grade ≥ III occurred in 2% and 7% of patients, respectively. A total of four men experienced grade IV toxicity (three GI, one genitourinary). SBRT treatment results in excellent biochemical control rates at 5 years for LR and IR PCa patients although doses greater than 47.5 Gy in five fractions led to increased severe late toxicity. •Results of a multi-institutional study of stereotactic body radiation therapy for prostate cancer are reported.•Doses up to 47.5 Gy in five fractions resulted in high control with acceptable toxicity.•Fifty gray in five fractions was associated with an increase in late high grade toxicity.•Three and five year biochemical control rates are 100 and 98.6% respectively.
Details
- Title: Subtitle
- Stereotactic body radiation therapy for low and intermediate risk prostate cancer—Results from a multi-institutional clinical trial
- Creators
- Raquibul Hannan - Department of Radiation Oncology, University of Texas Southwestern Medical Center, USAVasu Tumati - Department of Radiation Oncology, University of Texas Southwestern Medical Center, USAXian-Jin Xie - Department of Clinical Sciences, University of Texas Southwestern Medical Center, USAL. Chinsoo Cho - Department of Radiation Oncology, University of Minnesota, USABrian D Kavanagh - Department of Radiation Oncology, University of Colorado, USAJeffrey Brindle - Department of Radiation Oncology, Prairie Lakes Hospital, USADavid Raben - Department of Radiation Oncology, University of Colorado, USAAkash Nanda - Department of Radiation Oncology, Orlando Health, USASusan Cooley - Department of Radiation Oncology, University of Texas Southwestern Medical Center, USAD.W. Nathan Kim - Texas Oncology-Waco, USADavid Pistenmaa - Radiation Research Program, NCI, USAYair Lotan - Department of Urology, University of Texas Southwestern Medical Center, USARobert Timmerman - Department of Radiation Oncology, University of Texas Southwestern Medical Center, USA
- Resource Type
- Journal article
- Publication Details
- European Journal of Cancer, Vol.59, pp.142-151
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.ejca.2016.02.014
- PMID
- 27035363
- ISSN
- 0959-8049
- eISSN
- 1879-0852
- Grant note
- PC061629 / US Department of Defense
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Preventive and Community Dentistry; Biostatistics; Dental Research
- Record Identifier
- 9983917657202771
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