Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates

Svjetlana Miocinovic; Jianyu Zhang; Weidong Xu; Gary S Russo; Jerrold L Vitek; Cameron C McIntyre

doi:10.1016/j.jneumeth.2006.12.007

Back

Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates

Journal article

Peer reviewed

Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates

Svjetlana Miocinovic, Jianyu Zhang, Weidong Xu, Gary S Russo, Jerrold L Vitek and Cameron C McIntyre

Journal of neuroscience methods, Vol.162(1-2), pp.32-41

05/15/2007

DOI: 10.1016/j.jneumeth.2006.12.007

PMCID: PMC2075353

PMID: 17275094

Files and links (1)

url

http://doi.org/10.1016/j.jneumeth.2006.12.007View

Open Access

Abstract

Methodologies for stereotactic neurosurgery and neurophysiological microelectrode recordings (MER) in non-human primate research typically rely on brain atlases that are not customized to the individual animal, and require paper records of MER data. To address these limitations, we developed a software tool (Cicerone) that enables simultaneous interactive 3D visualization of the neuroanatomy, neurophysiology, and neurostimulation data pertinent to deep brain stimulation (DBS) research studies in non-human primates. Cicerone allows for analysis of co-registered magnetic resonance images (MRI), computed tomography (CT) scans, 3D brain atlases, MER data, and DBS electrode(s) with predictions of the volume of tissue activated (VTA) as a function of the stimulation parameters. We used Cicerone to aid the implantation of DBS electrodes in two parkinsonian rhesus macaques, targeting the subthalamic nucleus in one monkey and the globus pallidus in the other. Cicerone correctly predicted the anatomical position of 79% and 73% of neurophysiologically defined MER sites in the two animals, respectively. In contrast, traditional 2D print atlases achieved 61% and 48% accuracy. Our experience suggests that Cicerone can improve anatomical targeting, enhance electrophysiological data visualization, and augment the design of stimulation experiments.

Visualization

Deep brain stimulation

Monkey

Stereotactic neurosurgery

Software

Surgical planning

Microelectrode recording

Details

Title: Subtitle: Stereotactic neurosurgical planning, recording, and visualization for deep brain stimulation in non-human primates
Creators: Svjetlana Miocinovic - Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
Jianyu Zhang - Department of Neurosciences, Cleveland Clinic, 9500 Euclid Avenue NC30, Cleveland, OH 44195, USA
Weidong Xu - Department of Neurosciences, Cleveland Clinic, 9500 Euclid Avenue NC30, Cleveland, OH 44195, USA
Gary S Russo - Department of Neurosciences, Cleveland Clinic, 9500 Euclid Avenue NC30, Cleveland, OH 44195, USA
Jerrold L Vitek - Department of Neurosciences, Cleveland Clinic, 9500 Euclid Avenue NC30, Cleveland, OH 44195, USA
Cameron C McIntyre - Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
Resource Type: Journal article
Publication Details: Journal of neuroscience methods, Vol.162(1-2), pp.32-41
DOI: 10.1016/j.jneumeth.2006.12.007
PMID: 17275094
PMCID: PMC2075353
NLM abbreviation: J Neurosci Methods
ISSN: 0165-0270
eISSN: 1872-678X
Publisher: Elsevier B.V
Language: English
Date published: 05/15/2007
Academic Unit: Iowa Neuroscience Institute; Anesthesia
Record Identifier: 9984007169402771

Metrics

20 Record Views

68 Times Cited - Web of Science