Journal article
Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists
Journal of natural products (Washington, D.C.), Vol.77(2), pp.311-319
02/28/2014
DOI: 10.1021/np4009046
PMCID: PMC3993902
PMID: 24456556
Abstract
The natural stilbene pawhuskin A has been shown to function as an opioid receptor antagonist, with preferential binding to the κ receptor. This finding encouraged assembly of a set of analogues to probe the importance of key structural features. Assays on these compounds determined that one (compound 29) shows potent opioid receptor binding activity and significantly improved selectivity for the κ receptor. These studies begin to illuminate the structural features of these non-nitrogenous opioid receptor antagonists that are required for activity.
Details
- Title: Subtitle
- Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists
- Creators
- Alyssa M Hartung - Department of Chemistry, The University of Iowa , Chemistry Building, Iowa City, Iowa 52242, United StatesJohn A BeutlerHernán A NavarroDavid F WiemerJeffrey D Neighbors
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.77(2), pp.311-319
- Publisher
- United States
- DOI
- 10.1021/np4009046
- PMID
- 24456556
- PMCID
- PMC3993902
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Grant note
- R03 DA026573 / NIDA NIH HHS DA02-6573 / NIDA NIH HHS Intramural NIH HHS
- Language
- English
- Date published
- 02/28/2014
- Academic Unit
- Neuroscience and Pharmacology; Chemistry
- Record Identifier
- 9983985875702771
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