Journal article
Stimulant Drugs of Abuse and Cardiac Arrhythmias
Circulation. Arrhythmia and electrophysiology, Vol.15(1), pp.e010273-83
01/2022
DOI: 10.1161/CIRCEP.121.010273
PMCID: PMC8766923
PMID: 34961335
Abstract
Nonmedical use of prescription and nonprescription drugs is a worldwide epidemic, rapidly growing in magnitude with deaths because of overdose and chronic use. A vast majority of these drugs are stimulants that have various effects on the cardiovascular system including the cardiac rhythm. Drugs, like cocaine and methamphetamine, have measured effects on the conduction system and through several direct and indirect pathways, utilizing multiple second messenger systems, change the structural and electrical substrate of the heart, thereby promoting cardiac dysrhythmias. Substituted amphetamines and cocaine affect the expression and activation kinetics of multiple ion channels and calcium signaling proteins resulting in EKG changes, and atrial and ventricular brady and tachyarrhythmias. Preexisting conditions cause substrate changes in the heart, which decrease the threshold for such drug-induced cardiac arrhythmias. The treatment of cardiac arrhythmias in patients who take drugs of abuse may be specialized and will require an understanding of the unique underlying mechanisms and necessitates a multidisciplinary approach. The use of primary or secondary prevention defibrillators in drug abusers with chronic systolic heart failure is both sensitive and controversial. This review provides a broad overview of cardiac arrhythmias associated with stimulant substance abuse and their management.
Details
- Title: Subtitle
- Stimulant Drugs of Abuse and Cardiac Arrhythmias
- Creators
- Paari Dominic - Louisiana State University Health Sciences Center ShreveportJavaria Ahmad - Louisiana State University Health Sciences Center ShreveportHajra Awwab - Louisiana State University Health Sciences Center ShreveportMd. Shenuarin Bhuiyan - Louisiana State University Health Sciences Center ShreveportChristopher G. Kevil - Louisiana State University Health Sciences Center ShreveportNicholas E. Goeders - Louisiana State University Health Sciences Center ShreveportKevin S. Murnane - Louisiana State University Health Sciences Center ShreveportJames C. Patterson - Louisiana State University Health Sciences Center ShreveportKristin E. Sandau - Bethel UniversityRakesh Gopinathannair - Regional Medical CenterBrian Olshansky - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Circulation. Arrhythmia and electrophysiology, Vol.15(1), pp.e010273-83
- DOI
- 10.1161/CIRCEP.121.010273
- PMID
- 34961335
- PMCID
- PMC8766923
- ISSN
- 1941-3149
- eISSN
- 1941-3084
- Language
- English
- Date published
- 01/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984367117202771
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