Journal article
Stimulatory effects of halothane and isoflurane on fluoride release and cytochrome P-450 loss caused by metabolism of 2-chloro-1,1-difluoroethene, a halothane metabolite
Anesthesia and analgesia, Vol.66(11), pp.1141-1147
11/1987
PMID: 2889401
Abstract
The structural similarity of the halothane metabolite, 2-chloro-1,1-difluoroethene (CDE), to haloethenes that are metabolized by and inactivate cytochrome P-450, suggests that CDE may undergo secondary metabolism and degrade these isozymes. This possibility was examined in hepatic microsomes by determining fluoride release and cytochrome P-450 loss due to CDE metabolism in the presence of several anesthetics. CDE alone decreased cytochrome P-450 from phenobarbital-treated rats by as much as 37%, but the addition of isoflurane or halothane to incubations containing CDE increased the loss of cytochrome P-450 nearly twofold. Fluoride release was enhanced approximately 2.5 to 3 times by halothane or isoflurane; however, fluroxene inhibited fluoride release and did not enhance the loss of cytochrome P-450. Extrapolation of these results to the clinical situation suggests that the metabolism of CDE produced during halothane anesthesia and the accompanying cytochrome P-450 loss may contribute to the inhibition of drug metabolism produced by halothane.
Details
- Title: Subtitle
- Stimulatory effects of halothane and isoflurane on fluoride release and cytochrome P-450 loss caused by metabolism of 2-chloro-1,1-difluoroethene, a halothane metabolite
- Creators
- Max T Baker - Department of Anesthesia, College of Medicine, University of Iowa, Iowa City 52242James N BatesSusan V Leff
- Resource Type
- Journal article
- Publication Details
- Anesthesia and analgesia, Vol.66(11), pp.1141-1147
- Publisher
- United States
- PMID
- 2889401
- ISSN
- 0003-2999
- eISSN
- 1526-7598
- Grant note
- RRO5372 / NCRR NIH HHS
- Language
- English
- Date published
- 11/1987
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006402402771
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