Journal article
Stirring up controversy with a voltage sensor paddle
Trends in neurosciences (Regular ed.), Vol.27(6), pp.303-307
06/2004
DOI: 10.1016/j.tins.2004.03.008
PMID: 15165733
Abstract
Neurons owe their exquisite electrical excitability to voltage-gated ion channels. By creating and shaping the action potential, these voltage-sensitive proteins supply the neuron with crucial communication skills. A steady stream of experimental results, arising from numerous laboratories and employing a diverse repertoire of techniques, has produced a consensus model of the way voltage-gated ion channels sense and respond to changes in membrane potential. In contrast to this consensus mechanism, recent studies of the voltage-gated K(+) channel KvAP suggest a strikingly different mode of action. In this review, these disparate models are compared and critically discussed.
Details
- Title: Subtitle
- Stirring up controversy with a voltage sensor paddle
- Creators
- Christopher A Ahern - Department of Physiology, Institute of Hyperexcitability, Jefferson Medical College, 1020 Locust Street, Philadelphia, PA 19107, USARichard Horn
- Resource Type
- Journal article
- Publication Details
- Trends in neurosciences (Regular ed.), Vol.27(6), pp.303-307
- Publisher
- England
- DOI
- 10.1016/j.tins.2004.03.008
- PMID
- 15165733
- ISSN
- 0166-2236
- eISSN
- 1878-108X
- Language
- English
- Date published
- 06/2004
- Academic Unit
- Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984070101002771
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