Journal article
Stopping and slowing manual and spoken responses: Similar oscillatory signatures recorded from the subthalamic nucleus
Brain and language, Vol.176, pp.1-10
01/2018
DOI: 10.1016/j.bandl.2017.10.009
PMID: 29125966
Abstract
•Similar STN frequency-specific changes for the control of spoken and manual responses.•Suggesting generalizable processes of response control across effectors.•STN alpha band is related to slowing responses and beta band is related to stopping.•Right-lateralized STN beta profile during vocal stopping, implications for stuttering.
Response control in the forms of stopping and slowing responses is thought to be implemented by a frontal-subcortical network, which includes the subthalamic nucleus (STN). For manual control, stopping is linked to STN beta (13–30 Hz) and slowing responses are linked to lower frequencies (<12 Hz). Whether similar STN oscillatory activities are associated with the control of spoken responses is not clear. We studied 16 patients with STN LFP recordings during manual and vocal stop signal tasks in two experiments. We found increased beta activities for stopping spoken responses, similar to manual stopping. However, unlike manual stopping, stopping spoken responses elicited a right-lateralized beta power increase, which may be related to previously reported hyperactivity of right-sided motor control regions in stuttering. We additionally studied STN power changes associated with slowing responses in the same stop-signal tasks by comparing slower vs. faster go trials. Now, rather than beta, there was an alpha power increase after Go cues, which remained elevated only in slower Go trials in both the vocal and manual tasks. These data show that different types of response control are generalizable across effectors and relate to different frequencies recorded from the STN.
Details
- Title: Subtitle
- Stopping and slowing manual and spoken responses: Similar oscillatory signatures recorded from the subthalamic nucleus
- Creators
- Ayda Ghahremani - Institute of Medical Science, University of Toronto, Toronto, ON, CanadaJan R Wessel - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52245, USAKaviraja Udupa - Krembil Research Institute, Toronto, ON, CanadaBogdan Neagu - Krembil Research Institute, Toronto, ON, CanadaPing Zhuang - Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, ChinaUtpal Saha - Krembil Research Institute, Toronto, ON, CanadaSuneil K Kalia - Krembil Research Institute, Toronto, ON, CanadaMojgan Hodaie - Krembil Research Institute, Toronto, ON, CanadaAndres M Lozano - Krembil Research Institute, Toronto, ON, CanadaAdam R Aron - Department of Psychology, University of California San Diego, La Jolla, CA 92093, USARobert Chen - Krembil Research Institute, Toronto, ON, Canada
- Resource Type
- Journal article
- Publication Details
- Brain and language, Vol.176, pp.1-10
- DOI
- 10.1016/j.bandl.2017.10.009
- PMID
- 29125966
- NLM abbreviation
- Brain Lang
- ISSN
- 0093-934X
- eISSN
- 1090-2155
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/501100000024, name: Canadian Institutes of Health Research; name: James S McDonnell Scholar Award
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002471302771
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