Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice

Vladimir Shusterman; Irmute Usiene; Chivonne Harrigal; Joon Sup Lee; Toru Kubota; Arthur M Feldman; Barry London

doi:10.1152/ajpheart.00917.2001

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Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice

Journal article

Peer reviewed

Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice

Vladimir Shusterman, Irmute Usiene, Chivonne Harrigal, Joon Sup Lee, Toru Kubota, Arthur M Feldman and Barry London

American journal of physiology. Heart and circulatory physiology, Vol.282(6), pp.H2076-2083

06/2002

DOI: 10.1152/ajpheart.00917.2001

PMID: 12003814

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Abstract

Transgenic mice are widely used to study cardiac function, but strain-dependent differences in autonomic nervous system activity (ANSA) have not been explored. We compared 1) short-term pharmacological responses of cardiac rhythm in FVB vs. C57Black6/SV129 wild-type mice and 2) long-term physiological dynamics of cardiac rhythm and survival in tumor necrosis factor (TNF)-alpha transgenic mice with heart failure (TNF-alpha mice) on defined backgrounds. Ambulatory telemetry electrocardiographic recordings and response to saline, adrenergic, and cholinergic agents were examined in FVB and C57Black6/SV129 mice. In FVB mice, baseline heart rate (HR) was higher and did not change after injection of isoproterenol or atropine but decreased with propranolol. In C57Black6/SV129 mice, HR did not change with propranolol but increased with isoproterenol or atropine. Mean HR, but not indexes of HR variability, was an excellent predictor of response to autonomic agents. The proportion of surviving animals was higher in TNF-alpha mice on an FVB background than on a mixed FVB/C57Black6 background. The homeostatic states of ANSA are strain specific, which can explain the interstrain differences in mean HR, pharmacological responses, and survival of animals with congestive heart failure. Strain-specific differences should be considered in selecting the strains of mice used for transgenic and gene targeting experiments.

Species Specificity

Tumor Necrosis Factor-alpha - genetics

Heart Failure - physiopathology

Male

Adrenergic alpha-Antagonists - pharmacology

Adrenergic beta-Antagonists - pharmacology

Heart Rate - drug effects

Propranolol - pharmacology

Female

Receptors, Adrenergic, alpha-1 - physiology

Heart Failure - mortality

Genetic Predisposition to Disease

Receptors, Adrenergic, alpha-1 - drug effects

Mice, Inbred C57BL

Autonomic Nervous System - physiology

Adrenergic beta-Agonists - pharmacology

Atropine - pharmacology

Heart Failure - genetics

Mice, Transgenic

Survival Rate

Circadian Rhythm

Animals

Methoxamine - pharmacology

Isoproterenol - pharmacology

Receptors, Adrenergic, alpha - physiology

Tumor Necrosis Factor-alpha - physiology

Mice

Details

Title: Subtitle: Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice
Creators: Vladimir Shusterman - Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. shustermanv@msx.upmc.edu
Irmute Usiene
Chivonne Harrigal
Joon Sup Lee
Toru Kubota
Arthur M Feldman
Barry London
Resource Type: Journal article
Publication Details: American journal of physiology. Heart and circulatory physiology, Vol.282(6), pp.H2076-2083
Publisher: United States
DOI: 10.1152/ajpheart.00917.2001
PMID: 12003814
ISSN: 0363-6135
eISSN: 1522-1539
Grant note: R01-HL-66096 / NHLBI NIH HHS P50-HL-52338 / NHLBI NIH HHS R01-HL-58030 / NHLBI NIH HHS R01-HL-60032 / NHLBI NIH HHS
Language: English
Date published: 06/2002
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984025338802771

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