Journal article
Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation
International journal for numerical methods in biomedical engineering, Vol.35(10), pp.e3238-n/a
10/2019
DOI: 10.1002/cnm.3238
PMCID: PMC6785367
PMID: 31318162
Abstract
The purpose of this study was to assess the potential for optimization of mechanical ventilator waveforms using multiple frequencies of oscillatory flow delivered simultaneously to minimize the risk of ventilator-induced lung injury (VILI) associated with regional strain, strain rate, and mechanical power. Optimization was performed using simulations of distributed oscillatory flow and gas transport in a computational model of anatomically derived branching airway segments and viscoelastic terminal acini under healthy and injured conditions. Objective functions defined by regional strain or strain rate were minimized by single-frequency ventilation waveforms using the highest or lowest frequencies available, respectively. However, a mechanical power objective function was minimized by a combination of multiple frequencies delivered simultaneously. This simulation study thus demonstrates the potential for multifrequency oscillatory ventilation to reduce regional mechanical power in comparison to single-frequency ventilation, and thereby reduce the risk of VILI.
Details
- Title: Subtitle
- Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation
- Creators
- Jacob Herrmann - Department of Anesthesia, University of Iowa, Iowa City, IowaMerryn H Tawhai - Auckland Bioengineering Institute, The University of Auckland, Auckland, New ZealandDavid W Kaczka - Department of Radiology, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- International journal for numerical methods in biomedical engineering, Vol.35(10), pp.e3238-n/a
- Publisher
- England
- DOI
- 10.1002/cnm.3238
- PMID
- 31318162
- PMCID
- PMC6785367
- ISSN
- 2040-7947
- eISSN
- 2040-7947
- Grant note
- R41 HL140640 / NHLBI NIH HHS
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia
- Record Identifier
- 9984007295302771
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