Strength in numbers: Proteins travel as condensates to reinforce cell-cell junctions under stress

Jiarui Jiang; Katheryn E Rothenberg

doi:10.1083/jcb.202604040

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Strength in numbers: Proteins travel as condensates to reinforce cell-cell junctions under stress

Journal article

Peer reviewed

Strength in numbers: Proteins travel as condensates to reinforce cell-cell junctions under stress

Jiarui Jiang and Katheryn E Rothenberg

The Journal of cell biology, Vol.225(6), e202604040

06/01/2026

DOI: 10.1083/jcb.202604040

PMID: 42171593

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Abstract

Cell-cell junctions under stress recruit proteins to reinforce adhesion, but how these proteins are rapidly delivered is unclear. In this issue, Zheng et al. (https://doi.org/10.1083/jcb.202601182) identify a mechanism whereby the adhesion protein Canoe/Afadin travels along cell boundaries to vertices under tension in optimal-sized condensates.

Animals

Cell Adhesion

Humans

Intercellular Junctions - metabolism

Stress, Physiological

Details

Title: Subtitle: Strength in numbers: Proteins travel as condensates to reinforce cell-cell junctions under stress
Creators: Jiarui Jiang - University of Iowa
Katheryn E Rothenberg - University of Iowa
Resource Type: Journal article
Publication Details: The Journal of cell biology, Vol.225(6), e202604040
DOI: 10.1083/jcb.202604040
PMID: 42171593
NLM abbreviation: J Cell Biol
ISSN: 1540-8140
eISSN: 1540-8140
Publisher: Rockefeller University Press
Language: English
Date published: 06/01/2026
Academic Unit: Biology
Record Identifier: 9985164608902771

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