Journal article
Strengthening of top-down frontal cognitive control networks underlying the development of inhibitory control: a functional magnetic resonance imaging effective connectivity study
The Journal of neuroscience, Vol.30(46), pp.15535-15545
11/17/2010
DOI: 10.1523/jneurosci.2825-10.2010
PMCID: PMC2995693
PMID: 21084608
Abstract
The ability to voluntarily inhibit responses to task-irrelevant stimuli, which is a fundamental component of cognitive control, has a protracted development through adolescence. Previous human developmental imaging studies have found immaturities in localized brain activity in children and adolescents. However, little is known about how these regions integrate with age to form the distributed networks known to support cognitive control. In the present study, we used Granger causality analysis to characterize developmental changes in effective connectivity underlying inhibitory control (antisaccade task) compared with reflexive responses (prosaccade task) in human participants. By childhood, few top-down connectivities were evident with increased parietal interconnectivity. By adolescence, connections from prefrontal cortex increased and parietal interconnectivity decreased. From adolescence to adulthood, there was evidence of increased number and strength of frontal connections to cortical regions as well as subcortical regions. Together, results suggest that developmental improvements in inhibitory control may be supported by age-related enhancements in top-down effective connectivity between frontal, oculomotor, and subcortical regions.
Details
- Title: Subtitle
- Strengthening of top-down frontal cognitive control networks underlying the development of inhibitory control: a functional magnetic resonance imaging effective connectivity study
- Creators
- Kai Hwang - Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. kah124@pitt.eduKaterina VelanovaBeatriz Luna
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.30(46), pp.15535-15545
- DOI
- 10.1523/jneurosci.2825-10.2010
- PMID
- 21084608
- PMCID
- PMC2995693
- NLM abbreviation
- J Neurosci
- ISSN
- 1529-2401
- eISSN
- 1529-2401
- Publisher
- United States
- Grant note
- K01 MH082123 / NIMH NIH HHS R01 MH067924-07 / NIMH NIH HHS R01 MH067924 / NIMH NIH HHS
- Language
- English
- Date published
- 11/17/2010
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002477602771
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