Journal article
Stress Hormones Regulate Interleukin-6 Expression by Human Ovarian Carcinoma Cells through a Src-dependent Mechanism
The Journal of biological chemistry, Vol.282(41), pp.29919-29926
10/12/2007
DOI: 10.1074/jbc.M611539200
PMID: 17716980
Abstract
Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine, interleukin 6 (IL-6), are known to be elevated in individuals experiencing chronic stress, but the mechanism(s) by which this cytokine is regulated and its role in tumor growth remain under investigation. Here we show that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells. Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression. These results demonstrate that stress hormones activate signaling pathways known to be critical in ovarian tumor progression.
Details
- Title: Subtitle
- Stress Hormones Regulate Interleukin-6 Expression by Human Ovarian Carcinoma Cells through a Src-dependent Mechanism
- Creators
- Monique B Nilsson - Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Guillermo Armaiz-Pena - Department of Gynecologic Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Rie Takahashi - Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90095Yvonne G Lin - Department of Gynecologic Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Jose Trevino - Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Yang Li - Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Nicholas Jennings - Department of Gynecologic Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Jesusa Arevalo - Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90095Susan K Lutgendorf - Department of Psychology, University of Iowa, Iowa City, Iowa 52241Gary E Gallick - Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Angela M Sanguino - Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Gabriel Lopez-Berestein - Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030Steven W Cole - Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90095Anil K Sood - Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.282(41), pp.29919-29926
- DOI
- 10.1074/jbc.M611539200
- PMID
- 17716980
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 10/12/2007
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065771802771
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