Journal article
Stress biology: Complexity and multifariousness in health and disease
Cell Stress and Chaperones, Vol.29(1), pp.143-157
02/01/2024
DOI: 10.1016/j.cstres.2024.01.006
PMCID: PMC10939078
PMID: 38311120
Abstract
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
Details
- Title: Subtitle
- Stress biology: Complexity and multifariousness in health and disease
- Creators
- Matthias Mayer - Heidelberg UniversityLaura Blair - University of South FloridaGregory Blatch - Higher Colleges of TechnologyThiago Borges - Massachusetts General HospitalAhmed Chadli - Augusta UniversityGabriela Chiosis - Memorial Sloan Kettering Cancer CenterAurélie de ThonelAlbena Dinkova-Kostova - University of DundeeHeath Ecroyd - University of WollongongAdrienne Edkins - Rhodes UniversityTakanori Eguchi - Okayama UniversityMonika Fleshner - University of Colorado BoulderKevin FoleySotirios Fragkostefanakis - Goethe University FrankfurtJason Gestwicki - University of California, San FranciscoPierre Goloubinoff - University of LausanneJennifer Heritz - SUNY Upstate Medical UniversityChristine Heske - National Cancer InstituteJonathan Hibshman - University of North Carolina at Chapel HillJenny Joutsen - Lapland Central HospitalWei Li - University of Southern CaliforniaMichael Lynes - University of ConnecticutMarc Mendillo - Northwestern UniversityNahid Mivechi - Augusta UniversityFortunate Mokoena - North-West UniversityYuka Okusha - Beth Israel Deaconess Medical CenterVeena Prahlad - Roswell Park Comprehensive Cancer CenterElizabeth Repasky - Roswell Park Comprehensive Cancer CenterSara Sannino - University of PittsburghFederica Scalia - University of PalermoReut Shalgi - Technion – Israel Institute of TechnologyLea Sistonen - Åbo Akademi UniversityEmily Sontag - Marquette UniversityPatricija van Oosten-Hawle - University of North Carolina at CharlotteAnniina Vihervaara - KTH Royal Institute of TechnologyAnushka Wickramaratne - National Cancer InstituteShawn Wang - Virginia Commonwealth UniversityTawanda Zininga - Stellenbosch University
- Resource Type
- Journal article
- Publication Details
- Cell Stress and Chaperones, Vol.29(1), pp.143-157
- DOI
- 10.1016/j.cstres.2024.01.006
- PMID
- 38311120
- PMCID
- PMC10939078
- NLM abbreviation
- Cell Stress Chaperones
- ISSN
- 1355-8145
- eISSN
- 1466-1268
- Publisher
- Elsevier
- Language
- English
- Date published
- 02/01/2024
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984697740202771
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