Stress, inflammation, and eicosanoids: an emerging perspective

Sujanitha Umamaheswaran; Santosh K Dasari; Peiying Yang; Susan K Lutgendorf; Anil K Sood

doi:10.1007/s10555-018-9741-1

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Stress, inflammation, and eicosanoids: an emerging perspective

Journal article

Open access

Peer reviewed

Stress, inflammation, and eicosanoids: an emerging perspective

Sujanitha Umamaheswaran, Santosh K Dasari, Peiying Yang, Susan K Lutgendorf and Anil K Sood

Cancer and metastasis reviews, Vol.37(2-3), pp.203-211

09/2018

DOI: 10.1007/s10555-018-9741-1

PMCID: PMC6237279

PMID: 29948328

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https://www.ncbi.nlm.nih.gov/pmc/articles/6237279View

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Abstract

Clinical and experimental studies support the notion that adrenergic stimulation and chronic stress affect inflammation, metabolism, and tumor growth. Eicosanoids are also known to heavily influence inflammation while regulating certain stress responses. However, additional work is needed to understand the full extent of interactions between the stress-related pathways and eicosanoids. Here, we review the potential influences that stress, inflammation, and metabolic pathways have on each other, in the context of eicosanoids. Understanding the intricacies of such interactions could provide insights on how systemic metabolic effects mediated by the stress pathways can be translated into therapies for cancer and other diseases.

Lipid Metabolism

Neoplasms - metabolism

Disease Susceptibility

Neoplasms - etiology

Humans

Stress, Physiological

Inflammation - etiology

Inflammation - complications

Inflammation - metabolism

Animals

Metabolic Networks and Pathways

Eicosanoids - metabolism

Stress, Psychological - metabolism

Neoplasms - pathology

Stress, Psychological - complications

Details

Title: Subtitle: Stress, inflammation, and eicosanoids: an emerging perspective
Creators: Sujanitha Umamaheswaran - Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Santosh K Dasari - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Unit 1362, 1515 Holcombe Blvd., Houston, TX, 77030, USA
Peiying Yang - Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Susan K Lutgendorf - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA
Anil K Sood - Center for RNA Interference and Non-coding RNA, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. asood@mdanderson.org
Resource Type: Journal article
Publication Details: Cancer and metastasis reviews, Vol.37(2-3), pp.203-211
DOI: 10.1007/s10555-018-9741-1
PMID: 29948328
PMCID: PMC6237279
NLM abbreviation: Cancer Metastasis Rev
ISSN: 0167-7659
eISSN: 1573-7233
Publisher: Netherlands
Grant note: UH3 TR000943 / NCATS NIH HHS P50 CA217685 / NCI NIH HHS P30 CA016672 / NCI NIH HHS P50 CA083639 / NCI NIH HHS R01 CA109298 / NCI NIH HHS R01 CA193249 / NCI NIH HHS R35 CA209904 / NCI NIH HHS P30 CA086862 / NCI NIH HHS
Language: English
Date published: 09/2018
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984002351702771

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