Journal article
Stress integration by an ascending adrenergic-melanocortin circuit
Neuropsychopharmacology (New York, N.Y.), Vol.49(9), pp.1361-1372
02/07/2024
DOI: 10.1038/s41386-024-01810-9
PMCID: PMC11251172
PMID: 38326456
Abstract
Stress is thought to be an important contributing factor for eating disorders; however, neural substrates underlying the complex relationship between stress and appetite are not fully understood. Using in vivo recordings from awake behaving mice, we show that various acute stressors activate catecholaminergic nucleus tractus solitarius (NTS
) projections in the paraventricular hypothalamus (PVH). Remarkably, the resulting adrenergic tone inhibits MC4R-expressing neurons (PVH
), which are known for their role in feeding suppression. We found that PVH
silencing encodes negative valence in sated mice and is required for avoidance induced by visceral malaise. Collectively, these findings establish PVH
neurons as an effector of stress-activated brainstem adrenergic input in addition to the well-established hypothalamic-pituitary-adrenal axis. Convergent modulation of stress and feeding by PVH
neurons implicates NTS
→ PVH
input in stress-associated appetite disorders.
Details
- Title: Subtitle
- Stress integration by an ascending adrenergic-melanocortin circuit
- Creators
- Connor Laule - University of IowaNilufer Sayar-Atasoy - University of IowaIltan Aklan - University of IowaHyojin Kim - University of IowaTayfun Ates - University of IowaDebbie Davis - Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USADeniz Atasoy - Fraternal Order of Eagles Diabetes Research Center (FOEDRC), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA. deniz-atasoy@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Neuropsychopharmacology (New York, N.Y.), Vol.49(9), pp.1361-1372
- DOI
- 10.1038/s41386-024-01810-9
- PMID
- 38326456
- PMCID
- PMC11251172
- NLM abbreviation
- Neuropsychopharmacology
- eISSN
- 1740-634X
- Language
- English
- Electronic publication date
- 02/07/2024
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984557960302771
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