Stress risk factors and stress-related pathology: Neuroplasticity, epigenetics and endophenotypes

Jason J Radley; Mohamed Kabbaj; Lauren Jacobson; Willem Heydendael; Rachel Yehuda; James P Herman

doi:10.3109/10253890.2011.604751

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Stress risk factors and stress-related pathology: Neuroplasticity, epigenetics and endophenotypes

Journal article

Peer reviewed

Stress risk factors and stress-related pathology: Neuroplasticity, epigenetics and endophenotypes

Jason J Radley, Mohamed Kabbaj, Lauren Jacobson, Willem Heydendael, Rachel Yehuda and James P Herman

Stress (Amsterdam, Netherlands), Vol.14(5), pp.481-497

11/01/2011

DOI: 10.3109/10253890.2011.604751

PMCID: PMC3641164

PMID: 21848436

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https://www.ncbi.nlm.nih.gov/pmc/articles/3641164View

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Abstract

This paper highlights a symposium on stress risk factors and stress susceptibility, presented at the Neurobiology of Stress workshop in Boulder, CO, in June 2010. This symposium addressed factors linking stress plasticity and reactivity to stress pathology in animal models and in humans. Dr. J. Radley discussed studies demonstrating prefrontal cortical neuroplasticity and prefrontal control of hypothalamo-pituitary-adrenocortical axis function in rats, highlighting the emerging evidence of the critical role that this region plays in normal and pathological stress integration. Dr. M. Kabbaj summarized his studies of possible epigenetic mechanisms underlying behavioral differences in rat populations bred for differential stress reactivity. Dr. L. Jacobson described studies using a mouse model to explore the diverse actions of antidepressants in brain, suggesting mechanisms whereby antidepressants may be differentially effective in treating specific depression endophenotypes. Dr. R. Yehuda discussed the role of glucocorticoids in post-traumatic stress disorder (PTSD), indicating that low cortisol level may be a trait that predisposes the individual to development of the disorder. Furthermore, she presented evidence indicating that traumatic events can have transgenerational impact on cortisol reactivity and development of PTSD symptoms. Together, the symposium highlighted emerging themes regarding the role of brain reorganization, individual differences, and epigenetics in determining stress plasticity and pathology.

post-traumatic stress disorder

depression

glucocorticoids

hippocampus

Antidepressants

individual differences

Details

Title: Subtitle: Stress risk factors and stress-related pathology: Neuroplasticity, epigenetics and endophenotypes
Creators: Jason J Radley - Department of Psychology, University of Iowa
Mohamed Kabbaj - Program in Neurosciences, Department of Biomedical Sciences, Florida State University
Lauren Jacobson - Center for Neuropharmacology and Neuroscience, Albany Medical College
Willem Heydendael - Center for Neuropharmacology and Neuroscience, Albany Medical College
Rachel Yehuda - James J. Peters VA Medical Center and Mount Sinai School of Medicine
James P Herman - Department of Psychiatry, University of Cincinnati
Resource Type: Journal article
Publication Details: Stress (Amsterdam, Netherlands), Vol.14(5), pp.481-497
DOI: 10.3109/10253890.2011.604751
PMID: 21848436
PMCID: PMC3641164
NLM abbreviation: Stress
ISSN: 1025-3890
eISSN: 1607-8888
Publisher: Taylor & Francis
Language: English
Date published: 11/01/2011
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070795002771

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