Stressing the brain, fattening the body

Ling Yang; Gokhan S. Hotamisligil

doi:10.1016/j.cell.2008.09.030

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Stressing the brain, fattening the body

Ling Yang and Gokhan S. Hotamisligil

Cell, Vol.135(1), pp.20-22

10/03/2008

DOI: 10.1016/j.cell.2008.09.030

PMID: 18854151

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Abstract

Obesity is characterized by chronic activation of inflammatory pathways in peripheral tissues. In this issue, Zhang et al. (2008) demonstrate that inflammation also occurs in the central nervous system where it disrupts activity of the hypothalamus leading to resistance to leptin that is mediated by activation of IKK and the endoplasmic reticulum stress response.

Biochemistry & Molecular Biology

Cell Biology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Stressing the brain, fattening the body
Creators: Ling Yang - Harvard University
Gokhan S. Hotamisligil - Harvard University
Resource Type: Journal article
Publication Details: Cell, Vol.135(1), pp.20-22
DOI: 10.1016/j.cell.2008.09.030
PMID: 18854151
NLM abbreviation: Cell
ISSN: 0092-8674
eISSN: 1097-4172
Publisher: Elsevier
Number of pages: 4
Language: English
Date published: 10/03/2008
Academic Unit: Molecular Physiology and Biophysics; Anatomy and Cell Biology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984284354102771

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