Journal article
Striatal Volume Contributes to the Prediction of Onset of Huntington Disease in Incident Cases
Biological psychiatry (1969), Vol.71(9), pp.822-828
05/01/2012
DOI: 10.1016/j.biopsych.2011.07.030
PMCID: PMC3237730
PMID: 21907324
Abstract
Previous neuroimaging research indicates that brain atrophy in Huntington disease (HD) begins many years before movement abnormalities become severe enough to warrant diagnosis. Most clinical trials being planned for individuals in the prediagnostic stage of HD propose to use delay of disease onset as the primary outcome measure. Although formulas have been developed based on age and CAG repeat length, to predict when HD motor onset will occur, it would be useful to have additional measures that can improve the accuracy of prediction of disease onset.
The current study examined magnetic resonance imaging (MRI) measures of striatum and white matter volume in 85 individuals prospectively followed from pre-HD stage through diagnosable motor onset (incident cases) and 85 individuals individually matched with incident cases on CAG repeat length, sex, and age, who were not diagnosed with HD during the course of the study.
Volumes of striatum and white matter were significantly smaller in individuals who would be diagnosed 1 to 4 years following the initial MRI scan, compared with those who would remain in the pre-HD stage. Putamen volume was the measure that best distinguished between the two groups.
Results suggest that MRI volumetric measures may be helpful in selecting individuals for future clinical trials in pre-HD where HD motor onset is the primary outcome measure. In planning for multisite clinical trials in pre-HD, investigators may also want to consider using more objective measures, such as MRI volumes, in addition to onset of diagnosable movement disorder, as major outcome measures.
Details
- Title: Subtitle
- Striatal Volume Contributes to the Prediction of Onset of Huntington Disease in Incident Cases
- Creators
- Elizabeth H Aylward - Seattle Children's Research Institute, Seattle, WashingtonDawei Liu - Department of Biostatistics, The University of Iowa Carver College of Medicine, Iowa City, IowaPeggy C Nopoulos - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IowaChristopher A Ross - Division of Neurobiology, Department of Psychiatry, Johns Hopkins University, Baltimore, MarylandRonald K Pierson - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IowaJames A Mills - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IowaJeffrey D Long - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IowaJane S Paulsen - Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IowaPREDICT-HD Investigators and Coordinators of the Huntington Study Group
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.71(9), pp.822-828
- DOI
- 10.1016/j.biopsych.2011.07.030
- PMID
- 21907324
- PMCID
- PMC3237730
- NLM abbreviation
- Biol Psychiatry
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Publisher
- Elsevier Inc
- Grant note
- name: National Institutes of Health, National Institute of Neurological Disorders and Stroke, award: NS40068
- Language
- English
- Date published
- 05/01/2012
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics
- Record Identifier
- 9984004088502771
Metrics
18 Record Views