Journal article
Striatal and white matter predictors of estimated diagnosis for Huntington disease
Brain research bulletin, Vol.82(3), pp.201-207
2010
DOI: 10.1016/j.brainresbull.2010.04.003
PMCID: PMC2892238
PMID: 20385209
Abstract
Previous MRI studies with participants prior to manifest Huntington disease have been conducted in small single-site samples. The current study reports data from a systematic multi-national study during the prodromal period of Huntington disease and examines whether various brain structures make unique predictions about the proximity to manifest disease. MRI scans were acquired from 657 participants enrolled at 1 of 32 PREDICT-HD research sites. Only prodromal Huntington disease participants (those not meeting motor criteria for diagnosis) were included and subgrouped by estimated diagnosis proximity (Near, Mid, and Far) based upon a formula incorporating age and CAG-repeat length. Results show volumes of all three subgroups differed significantly from Controls for total brain tissue, cerebral spinal fluid, white matter, cortical gray matter, thalamus, caudate, and putamen. Total striatal volume demonstrated the largest differences between Controls and all three prodromal subgroups. Cerebral white matter offered additional independent power in the prediction of estimated proximity to diagnosis. In conclusion, this large cross-sectional study shows that changes in brain volume are detectable years to decades prior to estimated motor diagnosis of Huntington disease. This suggests that a clinical trial of a putative neuroprotective agent could begin as much as 15 years prior to estimated motor diagnosis in a cohort of persons at risk for but not meeting clinical motor diagnostic criteria for Huntington disease, and that neuroimaging (striatal and white matter volumes) may be among the best predictors of diagnosis proximity.
Details
- Title: Subtitle
- Striatal and white matter predictors of estimated diagnosis for Huntington disease
- Creators
- Jane S Paulsen - University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United StatesPeggy C Nopoulos - University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United StatesElizabeth Aylward - Seattle Children's Research Institute, Department of Imaging Science and Neuroscience/Neurodevelopment, Seattle, WA, United StatesChristopher A Ross - The Johns Hopkins University, Department of Psychiatry, Baltimore, MD, United StatesHans Johnson - University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United StatesVincent A Magnotta - University of Iowa Roy and Lucille Carver College of Medicine, Department of Radiology, Iowa City, IA, United StatesAndrew Juhl - University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United StatesRonald K Pierson - University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United StatesJames Mills - University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United StatesDouglas Langbehn - University of Iowa Roy and Lucille Carver College of Medicine, Department of Psychiatry, Iowa City, IA, United StatesMartha Nance - Park Nicollet Methodist Hospital, Department of Neurology, St. Louis Park, MN, United StatesPREDICT-HD Investigators and Coordinators of the Huntington's Study Group (HSG)
- Resource Type
- Journal article
- Publication Details
- Brain research bulletin, Vol.82(3), pp.201-207
- DOI
- 10.1016/j.brainresbull.2010.04.003
- PMID
- 20385209
- PMCID
- PMC2892238
- NLM abbreviation
- Brain Res Bull
- ISSN
- 0361-9230
- eISSN
- 1873-2747
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Electrical and Computer Engineering; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984004199702771
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