Journal article
Striatal function in relation to negative symptoms in schizophrenia
Psychological medicine, Vol.42(2), pp.267-282
02/2012
DOI: 10.1017/S003329171100119X
PMID: 21733291
Abstract
Previous studies have suggested that motivational aspects of executive functioning, which may be disrupted in schizophrenia patients with negative symptoms, are mediated in part by the striatum. Negative symptoms have been linked to impaired recruitment of both the striatum and the dorsolateral prefrontal cortex (DLPFC). Here we tested the hypothesis that negative symptoms are associated primarily with striatal dysfunction, using functional magnetic resonance imaging (fMRI).
Working-memory load-dependent activation and gray matter volumes of the striatum and DLPFC were measured using a region-of-interest (ROI) approach, in 147 schizophrenia patients and 160 healthy controls. In addition to testing for a linear relationships between striatal function and negative symptoms, we chose a second, categorical analytic strategy in which we compared three demographically and behaviorally matched subgroups: patients with a high burden of negative symptoms, patients with minimal negative symptoms, and healthy subjects.
There were no differences in striatal response magnitudes between schizophrenia patients and healthy controls, but right DLPFC activity was higher in patients than in controls. Negative symptoms were inversely associated with striatal, but not DLPFC, activity. In addition, patients with a high burden of negative symptoms exhibited significantly lower bilateral striatal, but not DLPFC, activation than schizophrenia patients with minimal negative symptoms. Working memory performance, antipsychotic exposure and changes in gray matter volumes did not account for these differences.
These data provide further evidence for a robust association between negative symptoms and diminished striatal activity. Future work will determine whether low striatal activity in schizophrenia patients could serve as a reliable biomarker for negative symptoms.
Details
- Title: Subtitle
- Striatal function in relation to negative symptoms in schizophrenia
- Creators
- S Ehrlich - MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USAA Yendiki - MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USAD N Greve - MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USAD S Manoach - MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USAB-C Ho - Department of Psychiatry, University of Iowa, Iowa City, IA, USAT White - Department of Psychiatry and the Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USAS C Schulz - Department of Psychiatry and the Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USAD C Goff - Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USAR L Gollub - MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USAD J Holt - MGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA
- Resource Type
- Journal article
- Publication Details
- Psychological medicine, Vol.42(2), pp.267-282
- Publisher
- England
- DOI
- 10.1017/S003329171100119X
- PMID
- 21733291
- ISSN
- 0033-2917
- eISSN
- 1469-8978
- Grant note
- P41RR14075 / NCRR NIH HHS 1U24 RR021382A / NCRR NIH HHS UL1 RR025758 / NCRR NIH HHS K23 MH076054 / NIMH NIH HHS M01 RR025758-01 / NCRR NIH HHS U24RR021992-01 / NCRR NIH HHS
- Language
- English
- Date published
- 02/2012
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003930602771
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