Striking a chord with healthy aging: memory system cooperation is related to preserved configural response learning in older adults

Michelle W Voss; Rachel Clark; Michael Freedberg; Timothy Weng; Eliot Hazeltine

doi:10.1016/j.neurobiolaging.2017.11.001

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Striking a chord with healthy aging: memory system cooperation is related to preserved configural response learning in older adults

Journal article

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Striking a chord with healthy aging: memory system cooperation is related to preserved configural response learning in older adults

Michelle W Voss, Rachel Clark, Michael Freedberg, Timothy Weng and Eliot Hazeltine

Neurobiology of aging, Vol.63, pp.44-53

03/2018

DOI: 10.1016/j.neurobiolaging.2017.11.001

PMCID: PMC7814217

PMID: 29223679

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https://www.ncbi.nlm.nih.gov/pmc/articles/7814217View

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Abstract

Evidence from tasks that primarily tap either hippocampal- or striatal-based memory systems suggests that although these systems often compete for control of behavior, aging is associated with greater cooperation between them. This may stem from altered prefrontal cortex function. Here, we use a configural response task designed to engage both memory systems to test how age affects their interaction with cortical regions including the prefrontal cortex. We found that although older and younger adults learned just as well, older adults showed greater initial activation in cortical networks associated with visuospatial-action mapping and resolving conflict for competing memory representations. Older adults also showed greater functional coupling of the striatum with the left inferior frontal gyrus, in parallel with similar hippocampal coupling to ventral visual regions as young adults. Overall, our results support the proposal that aging is associated with more cooperative memory systems, but we did not find that greater cooperation is associated with less interaction between the prefrontal cortex and core memory system structures during learning.

Healthy Aging - psychology

Cerebral Cortex - diagnostic imaging

Healthy Aging - physiology

Hippocampus - diagnostic imaging

Cognitive Aging - physiology

Learning - physiology

Magnetic Resonance Imaging

Cognitive Aging - psychology

Neuronal Plasticity

Corpus Striatum - physiology

Cerebral Cortex - physiology

Hippocampus - physiology

Corpus Striatum - diagnostic imaging

Prefrontal Cortex - physiology

Prefrontal Cortex - diagnostic imaging

Memory - physiology

Details

Title: Subtitle: Striking a chord with healthy aging: memory system cooperation is related to preserved configural response learning in older adults
Creators: Michelle W Voss - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, USA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA; Aging Mind and Brain Initiative (AMBI), The University of Iowa, Iowa City, IA, USA. Electronic address: michelle-voss@uiowa.edu
Rachel Clark - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA
Michael Freedberg - National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
Timothy Weng - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, USA
Eliot Hazeltine - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, USA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Neurobiology of aging, Vol.63, pp.44-53
DOI: 10.1016/j.neurobiolaging.2017.11.001
PMID: 29223679
PMCID: PMC7814217
NLM abbreviation: Neurobiol Aging
ISSN: 0197-4580
eISSN: 1558-1497
Publisher: United States
Grant note: T32 GM108540 / NIGMS NIH HHS
Language: English
Date published: 03/2018
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984001106702771

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