Journal article
Strontium-releasing fluorapatite glass-ceramics: Crystallization behavior, microstructure, and solubility
Journal of biomedical materials research. Part B, Applied biomaterials, Vol.106(4), pp.1421-1430
05/2018
DOI: 10.1002/jbm.b.33945
PMCID: PMC5740016
PMID: 28636267
Abstract
The purpose of this work was to investigate the effect of strontium partial replacement for calcium on the crystallization behavior, microstructure and solubility of fluorapatite glass-ceramics. Four glass compositions were prepared with increasing amounts of strontium partially replacing calcium. The crystallization behavior was analyzed by differential scanning calorimetry and X-ray diffraction (XRD). The microstructure was investigated by scanning electron microscopy. The chemical solubility was quantified according to ISO standard 10993-14. The amount of strontium released in solution after incubation in TRIS-HCl or citric acid buffer was measured by atomic absorption spectroscopy. XRD analyses revealed that partially substituted strontium-fluorapatite and strontium-åkermanite crystallized after strontium additions. The lattice cell volume of both phases increased linearly with the amount of strontium in the composition. Strontium additions led to a reduction in crystal size and an increase in crystal number density. The chemical solubility and amount of strontium released in solution increased linearly with the amount of strontium present in the composition in both TRIS-HCl and citric acid buffers. Total amounts of strontium released reached a maximum of 547 ± 80 ppm in TRIS-HCl and 1252 ± 290 ppm in citric acid buffer for the glass composition with the highest amount of strontium. For all strontium-containing compositions, the amount released in TRIS-HCl continued to increase between 70 and 120 h, indicating sustained release rather than burst release. © 2017 Wiley Periodicals, Inc. J Biomater Res Part B: 106B: 1421-1430, 2018.
Details
- Title: Subtitle
- Strontium-releasing fluorapatite glass-ceramics: Crystallization behavior, microstructure, and solubility
- Creators
- Isabelle Denry - Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, IowaOurania-Menti Goudouri - Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, 801 Newton Road, Iowa City, IowaJeffrey D Harless - Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, 801 Newton Road, Iowa City, IowaE M Hubbard - Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, 801 Newton Road, Iowa City, IowaJulie A Holloway - Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, Vol.106(4), pp.1421-1430
- Publisher
- United States
- DOI
- 10.1002/jbm.b.33945
- PMID
- 28636267
- PMCID
- PMC5740016
- ISSN
- 1552-4973
- eISSN
- 1552-4981
- Grant note
- R01 DE019972 / NIDCR NIH HHS
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Prosthodontics; Dental Research
- Record Identifier
- 9984066000002771
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