Journal article
Structural Abnormalities in the Frontal System in Schizophrenia: A Magnetic Resonance Imaging Study
Archives of general psychiatry, Vol.43(2), pp.136-144
02/01/1986
DOI: 10.1001/archpsyc.1986.01800020042006
PMID: 3947208
Abstract
Thirty-eight schizophrenics and 49 normal controls underwent magnetic resonance imaging. Midline sagittal cuts indicated that the schizophrenics had significantly smaller frontal lobes, as well as smaller cerebrums and craniums. The findings are consistent with some type of early developmental abnormality that might retard brain growth and therefore skull growth. These findings are confirmed on a smaller sample of patients on whom we have coronal cuts. Decreased cerebral and cranial size are associated with prominent negative symptoms, although decreased frontal size is not. Decreased cranial and cerebral size was also associated with impairment on some cognitive tests. These findings are consistent with the hypothesis that some schizophrenics may have a type of early developmental abnormality associated with prominent negative symptoms and cognitive impairment. Further, the results suggest that schizophrenics may have a type of structural frontal system impairment. Thus, they provide anatomic evidence for the "hypofrontality hypothesis."
Details
- Title: Subtitle
- Structural Abnormalities in the Frontal System in Schizophrenia: A Magnetic Resonance Imaging Study
- Creators
- Nancy AndreasenHenry A NasrallahVal DunnStephen C OlsonWilliam M GroveJames C EhrhardtJeffrey A CoffmanJudith H. W Crossett
- Resource Type
- Journal article
- Publication Details
- Archives of general psychiatry, Vol.43(2), pp.136-144
- DOI
- 10.1001/archpsyc.1986.01800020042006
- PMID
- 3947208
- NLM abbreviation
- Arch Gen Psychiatry
- ISSN
- 0003-990X
- eISSN
- 1538-3636
- Publisher
- American Medical Association
- Language
- English
- Date published
- 02/01/1986
- Academic Unit
- Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003418002771
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