Structural Evidence for the Evolution of Pyrogenic Toxin Superantigens

David T Mitchell; David G Levitt; Patrick M Schlievert; Douglas H Ohlendorf

doi:10.1007/s002390010116

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Structural Evidence for the Evolution of Pyrogenic Toxin Superantigens

Journal article

Peer reviewed

Structural Evidence for the Evolution of Pyrogenic Toxin Superantigens

David T Mitchell, David G Levitt, Patrick M Schlievert and Douglas H Ohlendorf

Journal of molecular evolution, Vol.51(6), pp.520-531

12/2000

DOI: 10.1007/s002390010116

PMID: 11116326

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Abstract

Pathogenic bacteria have evolved a wide variety of toxins to invade and attack host organisms. In particular, strains of the bacteria Staphylococcus aureus and Streptococcus pyogenes produce a family of pyrogenic toxin superantigens (PTSAgs) that can cause illness, e.g., toxic shock syndrome, or synergize with a number of other immune system disorders. The PTSAgs are all similar in size and have a conserved two-domain tertiary fold despite minimal amino acid sequence identity. The tertiary structure of PTSAg domain 1 is similar to the immunoglobulin binding motif of streptococcal proteins G and L. PTSAg domain 2 resembles members of the oligosaccharide/oligonucleotide binding fold family that includes the B subunits of the AB5 heat-labile enterotoxins, cholera toxin, pertussis toxin, and verotoxin. The strong structural homology between the pyrogenic toxins and other bacterial proteins suggests that the PTSAgs evolved through the recombination of two smaller β-strand motifs.

Protein conformation — Enterotoxins —Staphylococcus aureus— MHC class II — T-cell receptor — Toxic shock syndrome toxin-1

Details

Title: Subtitle: Structural Evidence for the Evolution of Pyrogenic Toxin Superantigens
Creators: David T Mitchell - Department of Biochemistry, University of Minnesota Medical School, 6-155 Jackson Hall, 321 Church St. SE, Minneapolis, MN 55455, USA US
David G Levitt - Department of Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA US
Patrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Box 196 UMHC, Minneapolis, MN 55455, USA US
Douglas H Ohlendorf - Department of Biochemistry, University of Minnesota Medical School, 6-155 Jackson Hall, 321 Church St. SE, Minneapolis, MN 55455, USA US
Resource Type: Journal article
Publication Details: Journal of molecular evolution, Vol.51(6), pp.520-531
Publisher: Springer-Verlag; Berlin/Heidelberg
DOI: 10.1007/s002390010116
PMID: 11116326
ISSN: 0022-2844
eISSN: 1432-1432
Language: English
Date published: 12/2000
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984002378002771

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