Journal article
Structural and Functional Characteristics of Healthy and Injured Porcine Lungs During Deflation: A Quantitative CT Imaging Analysis
Journal of applied physiology (1985), Vol.138(6), pp.1615-1627
06/01/2025
DOI: 10.1152/japplphysiol.00443.2024
PMCID: PMC12208140
PMID: 40411792
Abstract
The acute respiratory distress syndrome (ARDS) is characterized by pathologic and heterogeneous alterations in the mechanical properties of lung tissue. While several techniques exist that allow for assessment of global lung mechanics in health and disease, few techniques allow for quantitative assessment of regional mechanics, which is important for understanding the impact of therapeutic interventions on local structure-function relationships. X-ray computed tomography (CT) is a widely available imaging modality for assessment of regional lung structure, given its high spatial resolution, as well as its ability to provide detailed information on regional anatomic and pathologic features. Quantitative computed tomography (qCT) has evolved into an important tool for assessment of regional and global mechanical changes associated with deranged structure-function relationships in many lung diseases, especially ARDS. The purpose of this study was to determine how specific structural and functional characteristics of the acutely injured lung may be altered, as assessed with various qCT imaging metrics. Such alterations may serve as a template for characterizing the severity of ARDS in patients. We evaluated and compared pressure-volume relationships, distensibility, aeration, tissue texture, and parenchymal deformation in healthy and injured lungs of anesthetized pigs, using volumetric CT images obtained during static breath holds from 30 to 0 cmH
O airway pressure. We demonstrate how qCT imaging provides unique insight into structure-function changes associated with acute lung injury, and how such techniques may enhance our understanding of regional and global parenchymal mechanics in patients with ARDS or other forms of lung injury.
Details
- Title: Subtitle
- Structural and Functional Characteristics of Healthy and Injured Porcine Lungs During Deflation: A Quantitative CT Imaging Analysis
- Creators
- Emmanuel A Akor - University of IowaJian Gao - University of IowaJunfeng Guo - University of IowaBing Han - Morgan State UniversityAndrea F Cruz - University of Iowa, AnesthesiaJacob Herrmann - University of IowaSarah E Gerard - University of IowaMonica L Hawley - Oscillavent Inc. Iowa City, IAGary E Christensen - University of IowaJoseph M Reinhardt - University of IowaEric A Hoffman - University of IowaDavid W Kaczka - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.138(6), pp.1615-1627
- DOI
- 10.1152/japplphysiol.00443.2024
- PMID
- 40411792
- PMCID
- PMC12208140
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Grant note
- W81XWH-16-1-0434 / U.S. Department of Defense (DOD) W81XWH-21-1-0507 / U.S. Department of Defense (DOD) T32 HL144461-03 / HHS | National Institutes of Health (NIH) W911NF-23-1-0004 / U.S. Department of Defense (DOD)
- Language
- English
- Electronic publication date
- 05/24/2025
- Date published
- 06/01/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Radiation Oncology; Anesthesia; Radiation Research Laboratory; The Iowa Institute for Biomedical Imaging; Advanced Pulmonary Physiomic Imaging Laboratory; Holden Comprehensive Cancer Center; Internal Medicine
- Record Identifier
- 9984824228402771
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