Journal article
Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers
Korean journal of radiology, Vol.20(7), pp.1236-1245
07/2019
DOI: 10.3348/kjr.2019.0083
PMCID: PMC6609438
PMID: 31270987
Abstract
Objective
Considering the different prevalence rates of diseases such as asthma and chronic obstructive pulmonary disease in Asians relative to other races, Koreans may have unique airway structure and lung function. This study aimed to investigate unique features of airway structure and lung function based on quantitative computed tomography (QCT)-imaging metrics in the Korean Asian population (Koreans) as compared with the White American population (Whites).
Materials and Methods
QCT data of healthy non-smokers (223 Koreans vs. 70 Whites) were collected, including QCT structural variables of wall thickness (WT) and hydraulic diameter (Dh) and functional variables of air volume, total air volume change in the lung (ΔVair), percent emphysema-like lung (Emph%), and percent functional small airway disease-like lung (fSAD%). Mann-Whitney U tests were performed to compare the two groups.
Results
As compared with Whites, Koreans had smaller volume at inspiration, ΔVair between inspiration and expiration (p < 0.001), and Emph% at inspiration (p < 0.001). Especially, Korean females had a decrease of ΔVair in the lower lobes (p < 0.001), associated with fSAD% at the lower lobes (p < 0.05). In addition, Koreans had smaller Dh and WT of the trachea (both, p < 0.05), correlated with the forced expiratory volume in 1 second (R = 0.49, 0.39; all p < 0.001) and forced vital capacity (R = 0.55, 0.45; all p < 0.001).
Conclusion
Koreans had unique features of airway structure and lung function as compared with Whites, and the difference was clearer in female individuals. Discriminating structural and functional features between Koreans and Whites enables exploration of inter-racial differences of pulmonary disease in terms of severity, distribution, and phenotype.
Details
- Title: Subtitle
- Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers
- Creators
- Hyun Bin Cho - Kyungpook National UniversityKum Ju Chae - Jeonbuk National UniversityGong Yong Jin - Jeonbuk National UniversityJiwoong Choi - University of IowaChing Long Lin - University of IowaEric A Hoffman - University of IowaSally E Wenzel - University of PittsburghMario Castro - Washington University in St. LouisSean B Fain - University of Wisconsin–MadisonNizar N Jarjour - University of Wisconsin–MadisonMark L Schiebler - University of Wisconsin–MadisonR Graham Barr - Columbia University Irving Medical CenterNadia Hansel - Johns Hopkins UniversityChristopher B Cooper - University of California, Los AngelesEric C Kleerup - University of California, Los AngelesMeiLan K Han - University of MichiganPrescott G Woodruff - University of California, San FranciscoRichard E Kanner - University of UtahEugene R Bleecker - University of ArizonaStephen P Peters - Wake Forest UniversityWendy C Moore - Wake Forest UniversityChang Hyun Lee - Seoul National University HospitalSanghun Choi - Kyungpook National UniversityNational Heart, Lung and Blood Institute's SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) and Severe Asthma Research Program (SARP)
- Resource Type
- Journal article
- Publication Details
- Korean journal of radiology, Vol.20(7), pp.1236-1245
- DOI
- 10.3348/kjr.2019.0083
- PMID
- 31270987
- PMCID
- PMC6609438
- NLM abbreviation
- Korean J Radiol
- ISSN
- 1229-6929
- eISSN
- 2005-8330
- Grant note
- RE201806039 / Ministry of Environment 268200900017C / NIH HHS 268200900018C / NIH HHS 268200900015C / NIH HHS 109257-04 / NIH HHS 268200900014C / NIH HHS 109172-04 / NIH HHS 109168-04 / NIH HHS 109250-05 / NIH HHS NRF-2016R1D1A1B03936078 / National Research Foundation of Korea U10 HL109164 / NHLBI NIH HHS U10 HL109152-04 / NIH HHS RE201806027 / Ministry of Environment 268200900016C / NIH HHS 268200900020C / NIH HHS 109086-04 / NIH HHS P30 ES005605 / NIEHS NIH HHS 109046-04 / NIH HHS U01 HL137880 / NHLBI NIH HHS 109164 / NIH HHS NRF-2017R1D1A1B03034157 / National Research Foundation of Korea R01 HL112986 / NHLBI NIH HHS K24 HL137013 / NHLBI NIH HHS U10 HL109086 / NHLBI NIH HHS 268200900019C / NIH HHS S10 OD018526 / NIH HHS
- Language
- English
- Date published
- 07/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Health, Sport, and Human Physiology ; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984196558902771
Metrics
20 Record Views