Journal article
Structural brain abnormalities in adult males with clefts of the lip and/or palate
Genetics in medicine, Vol.4(1), pp.1-9
01/2002
DOI: 10.1097/00125817-200201000-00001
PMID: 11839951
Abstract
To evaluate brain morphology of adult males with nonsyndromic clefts of the lip and/or palate (NSCLP) in comparison to a matched healthy control group.
Brain structure was measured using quantitative analysis of magnetic resonance images.
Subjects with NSCLP had significant abnormalities in brain morphology consisting of abnormally enlarged anterior regions of the cerebrum, and decreased volumes of the posterior cerebrum and cerebellum. Overall, the most severely affected region was the left temporal lobe. Furthermore, these structural abnormalities were directly related to cognitive dysfunction.
These findings highlight the important relationship and interplay between face and brain development.
Details
- Title: Subtitle
- Structural brain abnormalities in adult males with clefts of the lip and/or palate
- Creators
- Peg Nopoulos - Department of Psychiatry, University of Iowa Hospital, Iowa City, Iowa 52242, USAStephanie BergJohn CanadyLynn RichmanDuane Van DemarkNancy C Andreasen
- Resource Type
- Journal article
- Publication Details
- Genetics in medicine, Vol.4(1), pp.1-9
- Publisher
- United States
- DOI
- 10.1097/00125817-200201000-00001
- PMID
- 11839951
- ISSN
- 1098-3600
- eISSN
- 1530-0366
- Grant note
- MH00625 / NIMH NIH HHS MH31593 / NIMH NIH HHS MH40856 / NIMH NIH HHS MHCRC 43271 / NIMH NIH HHS
- Language
- English
- Date published
- 01/2002
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology
- Record Identifier
- 9984003403402771
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