Journal article
Structural brain changes with lifetime trauma and re-experiencing symptoms is 5-HTTLPR genotype-dependent
European journal of psychotraumatology, Vol.11(1), p.1733247
12/31/2020
DOI: 10.1080/20008198.2020.1733247
PMCID: PMC7067154
PMID: 32194924
Abstract
Background: Findings on structural brain alterations following trauma are inconsistent due probably to heterogeneity in imaging studies and population, clinical presentations, genetic vulnerability, and selection of controls. This study examines whether trauma and re-experiencing symptoms are associated with specific alterations in grey matter volumes and if this varies according to 5-HTTLPR genotype. Methods: Structural MRI was used to acquire anatomical scans from 377 community-dwelling older adults. Quantitative regional estimates of 22 subregional volumes were derived using FreeSurfer software. Lifetime trauma was assessed using the validated Watson's PTSD inventory, which evaluates the most severe trauma experienced according to DSM criteria. Analyses adjusted for age, sex, total brain volume, head injury, and comorbidities. Results: Of the 212 participants reporting lifetime trauma, 35.4% reported re-experiencing symptoms and for 1.9%, this was severe enough to meet criteria for full threshold PTSD. In participants with the SS 5-HTTLPR genotype only, re-experiencing symptoms were associated with smaller volumes in middle and superior temporal, frontal (lateral orbital, rostral and caudal middle) and parietal (precuneus, inferior and superior) regions. The trauma-exposed participants without re-experiencing symptoms were not significantly different from the non-trauma-exposed participants except for smaller precuneus and superior parietal region in traumatized participants and a larger amygdala in traumatized women specifically. Conclusions: In the non-clinical sample, lifetime trauma and re-experiencing symptoms were associated with smaller volume in prefrontal, temporal and parietal cortex subregions, and this varied according to serotonergic genetic vulnerability, 5-HTTLPR SS individuals being most susceptible.
Details
- Title: Subtitle
- Structural brain changes with lifetime trauma and re-experiencing symptoms is 5-HTTLPR genotype-dependent
- Creators
- Marie-Laure Ancelin - InsermIsabelle Carriere - Neuropsychiatrie : Recherche Epidemiologique et CliniqueSylvaine Artero - Neuropsychiatrie : Recherche Epidemiologique et CliniqueJerome J. Maller - Monash Alfred Psychiatry Research centreChantal Meslin - Australian National UniversityAnne-Marie Dupuy - InsermKaren Ritchie - Neuropsychiatrie : Recherche Epidemiologique et CliniqueJoanne Ryan - Neuropsychiatrie : Recherche Epidemiologique et CliniqueIsabelle Chaudieu - Inserm
- Resource Type
- Journal article
- Publication Details
- European journal of psychotraumatology, Vol.11(1), p.1733247
- DOI
- 10.1080/20008198.2020.1733247
- PMID
- 32194924
- PMCID
- PMC7067154
- NLM abbreviation
- Eur J Psychotraumatol
- ISSN
- 2000-8198
- eISSN
- 2000-8066
- Publisher
- Taylor & Francis
- Number of pages
- 10
- Grant note
- Novartis 07 LVIE 004 / Agence Nationale de la Recherche; Agence Nationale de la Recherche (ANR) APP1135727 / National Health & Medical Research Council (NHMRC), Australia; National Health & Medical Research Council (NHMRC) of Australia France Alzheimer regional government of Languedoc-Roussillon; Region Occitanie
- Language
- English
- Date published
- 12/31/2020
- Academic Unit
- Radiology
- Record Identifier
- 9984848424602771
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