Journal article
Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps
Bioorganic & medicinal chemistry letters, Vol.14(12), pp.3093-3097
2004
DOI: 10.1016/j.bmcl.2004.04.018
PMID: 15149651
Abstract
Graphic
In this study the chemical modification of paroxetine was employed to determine which structural differences between the paroxetine-like and femoxetine-like selective serotonin reuptake inhibitors is responsible for the differential potency of these agents in the inhibition of
Staphylococcus aureus multidrug efflux pump systems.
Details
- Title: Subtitle
- Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps
- Creators
- Peng Wei - University of IowaGlenn W. Kaatz - Wayne State UniversityRobert J. Kerns - Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.14(12), pp.3093-3097
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.bmcl.2004.04.018
- PMID
- 15149651
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Language
- English
- Date published
- 2004
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984365890702771
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