Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins (l)

G Rhodes; M L Holland; D Wiesler; M Novotny; S A Moore; R G Peterson; D L Felten

doi:10.1007/BF01944536

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Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins (l)

Journal article

Peer reviewed

Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins (l)

G Rhodes, M L Holland, D Wiesler, M Novotny, S A Moore, R G Peterson and D L Felten

Experientia, Vol.38(1), pp.75-77

01/15/1982

DOI: 10.1007/BF01944536

PMID: 7056362

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Abstract

High resolution glass capillary gas chromatography and GC/MS were utilized to examine qualitative and quantitative variations from normal of urinary volatile metabolites of long-term alloxan and streptozotocin diabetic rats. Volatile metabolites were structurally compared with known neurotoxins to examine any possible relationship between these metabolites and the development of the diabetic polyneuropathy.

Animals

Gas Chromatography-Mass Spectrometry

Diabetic Neuropathies - etiology

Pyrroles - urine

Volatilization

Rats

Male

Methyl n-Butyl Ketone - urine

Neurotoxins - urine

Rats, Inbred Strains

Diabetes Mellitus - urine

Ketones - urine

Details

Title: Subtitle: Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins (l)
Creators: G Rhodes
M L Holland
D Wiesler
M Novotny
S A Moore
R G Peterson
D L Felten
Resource Type: Journal article
Publication Details: Experientia, Vol.38(1), pp.75-77
Publisher: Switzerland
DOI: 10.1007/BF01944536
PMID: 7056362
ISSN: 0014-4754
eISSN: 1420-9071
Grant note: 24349 / PHS HHS
Language: English
Date published: 01/15/1982
Academic Unit: Pathology
Record Identifier: 9984047614602771

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