Structure-Function Imaging of Lung Disease Using Ultrashort Echo Time MRI

Luis Torres; Jeff Kammerman; Andrew D Hahn; Wei Zha; Scott K Nagle; Kevin Johnson; Nathan Sandbo; Keith Meyer; Mark Schiebler; Sean B Fain

doi:10.1016/j.acra.2018.12.007

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Structure-Function Imaging of Lung Disease Using Ultrashort Echo Time MRI

Journal article

Peer reviewed

Structure-Function Imaging of Lung Disease Using Ultrashort Echo Time MRI

Luis Torres, Jeff Kammerman, Andrew D Hahn, Wei Zha, Scott K Nagle, Kevin Johnson, Nathan Sandbo, Keith Meyer, Mark Schiebler and Sean B Fain

Academic radiology, Vol.26(3), pp.431-441

03/2019

DOI: 10.1016/j.acra.2018.12.007

PMCID: PMC7032698

PMID: 30658930

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https://www.ncbi.nlm.nih.gov/pmc/articles/7032698View

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Abstract

Rationale and Objectives: The purpose of this review is to acquaint the reader with recent advances in ultrashort echo time (UTE) magnetic resonance imaging (MRI) of the lung and its implications for pulmonary MRI when used in conjunction with functional MRI technique. Materials and Methods: We provide an overview of recent technical advances of UTE and explore the advantages of combined structure-function pulmonary imaging in the context of restrictive and obstructive pulmonary diseases such as idiopathic pulmonary fibrosis (IPF) and cystic fibrosis (CF). Results:UTE MRI clearly shows the lung parenchymal changes due to IPF and CF. The use of UTE MRI, in conjunction with established functional lung MRI in chronic lung diseases, will serve to mitigate the need for computed tomography in children.Conclusion:Current limitations of UTE MRI include long scan times, poor delineation of thin-walled structures (e.g. cysts and reticulation) due to limited spatial resolution, low signal to noise ratio, and imperfect motion compensation. Despite these limitations, UTE MRI can now be considered as an alternative to multidetector computed tomography for the longitudinal follow-up of the morphological changes from lung diseases in neonates, children, and young adults, particularly as a complement to the unique functional capabilities of MRI.

Cystic Fibrosis

Magnetic Resonance Imaging

Adult

Child

Hyperpolarized gas

Idiopathic pulmonary fibrosis

Infant

Longitudinal studies

Lung

Perfusion

Xenon

Young adult

Details

Title: Subtitle: Structure-Function Imaging of Lung Disease Using Ultrashort Echo Time MRI
Creators: Luis Torres - University of Wisconsin–Madison
Jeff Kammerman - University of Wisconsin–Madison
Andrew D Hahn - University of Wisconsin–Madison
Wei Zha - University of Wisconsin–Madison
Scott K Nagle - University of Wisconsin–Madison
Kevin Johnson - University of Wisconsin–Madison
Nathan Sandbo - University of Wisconsin–Madison
Keith Meyer - University of Wisconsin–Madison
Mark Schiebler - University of Wisconsin–Madison
Sean B Fain - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Academic radiology, Vol.26(3), pp.431-441
DOI: 10.1016/j.acra.2018.12.007
PMID: 30658930
PMCID: PMC7032698
NLM abbreviation: Acad Radiol
ISSN: 1076-6332
eISSN: 1878-4046
Publisher: Elsevier Inc
Grant note: name: NIH/NHLBI, award: U10 HL109168, P01 HL070831, R01 HL126771; name: NIH/NCRR, award: S10 OD016394
Language: English
Date published: 03/2019
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984274957802771

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