Journal article
Structure, Function, and Regulation of the Junctophilin Family
Annual review of physiology, Vol.86(1), pp.123-147
02/12/2024
DOI: 10.1146/annurev-physiol-042022-014926
PMCID: PMC10922073
PMID: 37931168
Abstract
In both excitable and nonexcitable cells, diverse physiological processes are linked to different calcium microdomains within nanoscale junctions that form between the plasma membrane and endo-sarcoplasmic reticula. It is now appreciated that the junctophilin protein family is responsible for establishing, maintaining, and modulating the structure and function of these junctions. We review foundational findings from more than two decades of research that have uncovered how junctophilin-organized ultrastructural domains regulate evolutionarily conserved biological processes. We discuss what is known about the junctophilin family of proteins. Our goal is to summarize the current knowledge of junctophilin domain structure, function, and regulation and to highlight emerging avenues of research that help our understanding of the transcriptional, translational, and post-translational regulation of this gene family and its roles in health and during disease. Expected final online publication date for the Annual Review of Physiology, Volume 86 is February 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Details
- Title: Subtitle
- Structure, Function, and Regulation of the Junctophilin Family
- Creators
- Duane D. Hall - University of IowaHiroshi Takeshima - Kyoto UniversityLong-Sheng Song
- Resource Type
- Journal article
- Publication Details
- Annual review of physiology, Vol.86(1), pp.123-147
- DOI
- 10.1146/annurev-physiol-042022-014926
- PMID
- 37931168
- PMCID
- PMC10922073
- NLM abbreviation
- Annu Rev Physiol
- ISSN
- 0066-4278
- eISSN
- 1545-1585
- Language
- English
- Electronic publication date
- 11/06/2023
- Date published
- 02/12/2024
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9984506258202771
Metrics
12 Record Views