Journal article
Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides
Bioorganic & medicinal chemistry letters, Vol.9(13), pp.1819-1824
1999
DOI: 10.1016/S0960-894X(99)00291-7
PMID: 10406648
Abstract
On the basis of a systematic SAR analysis of substituted quinolines, a derivative
32 was synthesized that shows half-maximal inhibition of the immunostimulatory effect of CpG-oligodeoxynucleotides in vitro at the concentration of 0.24 nM.
On the basis of a systematic SAR analysis of substituted quinolines the powerful antagonist
32 (EC
50 = 0.24 nM) was synthesized.
Details
- Title: Subtitle
- Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides
- Creators
- Lucjan Strekowski - Department of Chemistry, Georgia State University, Atlanta, GA 30303, U.S.AOliwia Zegrocka - Department of Chemistry, Georgia State University, Atlanta, GA 30303, U.S.AMaged Henary - Department of Chemistry, Georgia State University, Atlanta, GA 30303, U.S.AMartial Say - Department of Chemistry, Georgia State University, Atlanta, GA 30303, U.S.AMaria J Mokrosz - Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 30–343 Krakow, PolandBarbara M Kotecka - Australian Army Malaria Institute, Brisbane, QLD 4052, AustraliaLori Manzel - Department of Medicine, Veterans Affairs Medical Center and University of Iowa, Iowa City, IA 52242, U.S.ADonald E Macfarlane - Department of Medicine, Veterans Affairs Medical Center and University of Iowa, Iowa City, IA 52242, U.S.A
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.9(13), pp.1819-1824
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0960-894X(99)00291-7
- PMID
- 10406648
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Language
- English
- Date published
- 1999
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094749602771
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