Journal article
Structure-activity relationship and bioactivity studies of neurotrophic trans -banglene
Organic & biomolecular chemistry, Vol.20(11), pp.2187-2193
03/01/2022
DOI: 10.1039/d2ob00016d
PMID: 35229853
Abstract
The synthesis and bioactivity of neurotrophic banglenes and derivatives is described, establishing a structure-activity relationship which enables future mechanistic studies. Neuritogenesis assays indicate that (-)
-banglene is the active enantiomer. Assays performed with and without NGF protein suggest that neurotrophic activity and potentiation of NGF activity by (-)
-banglene might be distinct unassociated processes. Interestingly, (-)
-banglene potentiation of NGF-induced neuritogenesis is unaffected by the presence of Erk1/2, Akt and Pkc inhibitors.
Details
- Title: Subtitle
- Structure-activity relationship and bioactivity studies of neurotrophic trans -banglene
- Creators
- Khyati Gohil - Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, CanadaM Zain H Kazmi - Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2, CanadaFlorence J Williams - Department of Chemistry, University of Iowa, Iowa City, IA, 52246, USA
- Resource Type
- Journal article
- Publication Details
- Organic & biomolecular chemistry, Vol.20(11), pp.2187-2193
- DOI
- 10.1039/d2ob00016d
- PMID
- 35229853
- eISSN
- 1477-0539
- Grant note
- DOI: 10.13039/501100000196, name: Canada Foundation for Innovation, award: IOF-34997; DOI: 10.13039/100015402, name: Canada Research Coordinating Committee, award: NFRFE-2018-00223
- Language
- English
- Date published
- 03/01/2022
- Academic Unit
- Iowa Neuroscience Institute; Chemistry
- Record Identifier
- 9984222822102771
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