Journal article
Structure and Mechanisms of SF2 DNA Helicases
Advances in experimental medicine and biology, Vol.767, pp.47-73
2013
DOI: 10.1007/978-1-4614-5037-5_3
PMID: 23161006
Abstract
Effective transcription, replication, and maintenance of the genome require a diverse set of molecular machines to perform the many chemical transactions that constitute these processes. Many of these machines use single-stranded nucleic acids as templates, and their actions are often regulated by the participation of nucleic acids in multimeric structures and macromolecular assemblies that restrict access to chemical information. Superfamily II (SF2) DNA helicases and translocases are a group of molecular machines that remodel nucleic acid lattices and enable essential cellular processes to use the information stored in the duplex DNA of the packaged genome. Characteristic accessory domains associated with the subgroups of the superfamily direct the activity of the common motor core and expand the repertoire of activities and substrates available to SF2 DNA helicases, translocases, and large multiprotein complexes containing SF2 motors. In recent years, single-molecule studies have contributed extensively to the characterization of this ubiquitous and essential class of enzymes.
Details
- Title: Subtitle
- Structure and Mechanisms of SF2 DNA Helicases
- Creators
- David C Beyer - Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA, USAMohamed Karem GhoneimMaria Spies
- Resource Type
- Journal article
- Publication Details
- Advances in experimental medicine and biology, Vol.767, pp.47-73
- Publisher
- United States
- DOI
- 10.1007/978-1-4614-5037-5_3
- PMID
- 23161006
- eISBN
- 1461450373; 9781461450375
- ISSN
- 0065-2598
- eISSN
- 2214-8019
- Language
- English
- Date published
- 2013
- Academic Unit
- Radiation Oncology; Anesthesia; Biochemistry and Molecular Biology
- Record Identifier
- 9984024542802771
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