Journal article
Structure in Dehydrated Trehalose Dihydrate—Evaluation of the Concept of Partial Crystallinity
Pharmaceutical research, Vol.23(10), pp.2356-2367
10/2006
DOI: 10.1007/s11095-006-9058-6
PMID: 16927180
Abstract
(i) To use trehalose as a model compound to evaluate the concept of crystallinity in pharmaceuticals. (ii) To understand the structural nature of dehydrated trehalose dihydrate.Trehalose dihydrate was dehydrated isothermally at several temperatures below 100°C and the anhydrous product was characterized by XRD, DSC and water vapor sorption.XRD and DSC suggested that the dehydration product was a partially crystalline α-polymorphic form of anhydrous trehalose
% MathType!MTEF!2!1!+-% feaaeaart1ev0aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbbjxAHX% garmWu51MyVXgatuuDJXwAK1uy0HwmaeHbfv3ySLgzG0uy0Hgip5wz% aebbnrfifHhDYfgasaacH8qrps0lbbf9q8WrFfeuY-Hhbbf9v8qqaq% Fr0xc9pk0xbba9q8WqFfea0-yr0RYxir-Jbba9q8aq0-yq-He9q8qq% Q8frFve9Fve9Ff0dmeaabaqaciGacaGaaeqabaWaaeWaeaaakeaada% qadaqaaiaabsfadaWgaaWcbaGaeqySdegabeaaaOGaayjkaiaawMca% aaaa!3BC5!
$${\left( {{\text{T}}_{\alpha } } \right)}$$
. An increase in the temperature of dehydration resulted in a decrease in lattice order. In agreement with earlier findings, the ordered regions in the dehydrated lattice
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$${\left( {{\text{T}}_{{\text{ $ \alpha $ }}} } \right)}$$
converted to the dihydrate at much lower RH values than amorphous trehalose. However, the lattice order in the dehydrated product dictated the RH at which this conversion was initiated—the higher the lattice order the lower this RH. The structural nature of these samples can be explained based on the one-state model of crystallinity. In dehydrated trehalose, there is a continuum in lattice order ranging from highly crystalline
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$${\text{T}}_{\alpha } $$
to a completely disordered (i.e., amorphous) state.The extent of lattice order in anhydrous trehalose
% MathType!MTEF!2!1!+-% feaaeaart1ev0aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbbjxAHX% garmWu51MyVXgatuuDJXwAK1uy0HwmaeHbfv3ySLgzG0uy0Hgip5wz% aebbnrfifHhDYfgasaacH8qrps0lbbf9q8WrFfeuY-Hhbbf9v8qqaq% Fr0xc9pk0xbba9q8WqFfea0-yr0RYxir-Jbba9q8aq0-yq-He9q8qq% Q8frFve9Fve9Ff0dmeaabaqaciGacaGaaeqabaWaaeWaeaaakeaada% qadaqaaiaabsfadaWgaaWcbaGaeqySdegabeaaaOGaayjkaiaawMca% aaaa!3BC5!
$${\left( {{\text{T}}_{\alpha } } \right)}$$
was dictated by the kinetics of water removal from trehalose dihydrate. The partially crystalline nature of anhydrous trehalose produced by dehydration could be described on a continuous scale of lattice order based on the one-state model of crystallinity.
Details
- Title: Subtitle
- Structure in Dehydrated Trehalose Dihydrate—Evaluation of the Concept of Partial Crystallinity
- Creators
- Meena Rani - Interpharm, Inc. 75 Adams Ave. Hauppauge NY 11788 USARamprakash Govindarajan - Department of Pharmaceutics University of Minnesota 308 Harvard St. S.E. Minneapolis MN 55455 USARahul Surana - Forest Laboratories Inc. 49 Mall Drive Commack NY 11725 USARaj Suryanarayanan - Department of Pharmaceutics University of Minnesota 308 Harvard St. S.E. Minneapolis MN 55455 USA
- Resource Type
- Journal article
- Publication Details
- Pharmaceutical research, Vol.23(10), pp.2356-2367
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- DOI
- 10.1007/s11095-006-9058-6
- PMID
- 16927180
- ISSN
- 0724-8741
- eISSN
- 1573-904X
- Language
- English
- Date published
- 10/2006
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065311902771
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