Journal article
Structure-mechanics and improved tableting performance of the drug-drug cocrystal metformin:salicylic acid
European journal of pharmaceutics and biopharmaceutics, Vol.153, pp.23-35
08/01/2020
DOI: 10.1016/j.ejpb.2020.05.031
PMID: 32504797
Abstract
Drug-drug cocrystals (DDC) represent a unique subset of pharmaceutical materials offering distinct advantages in combination therapies, pharmacokinetics, and patient compliance. However, their structure-function relationships are rarely reported despite its central importance in successful medicine. A material-sparing approach consisting of a molecular and structural perspective is reported to evaluate tabletability of a model DDC, metformin:salicylic acid, relative to its components: metformin HCl (MET) and sodium salicylate (SAL). MET alone displayed a very poor tabletability, which could be attributed to its isotropic and stiff interaction topology. SAL displayed a highly anisotropic interaction topology with layers of strongly hydrogen-bonded salicylate molecules promoting deformation and tabletability. This is also confirmed by its low moduli. DDC yielded intermediate stiffness and elastic anisotropy material with an improved plastic flow and overall better tabletability. Overall, DDC is a promising therapeutic class requiring the physical-mechanical evaluation to assure their processability to enjoy their therapeutic advantages.
Details
- Title: Subtitle
- Structure-mechanics and improved tableting performance of the drug-drug cocrystal metformin:salicylic acid
- Creators
- Jayshil A. Bhatt - Long Island UniversityDherya Bahl - University of IowaKenneth Morris - Long Island UniversityLewis L. Stevens - University of IowaRahul Haware - Long Island University
- Resource Type
- Journal article
- Publication Details
- European journal of pharmaceutics and biopharmaceutics, Vol.153, pp.23-35
- Publisher
- Elsevier
- DOI
- 10.1016/j.ejpb.2020.05.031
- PMID
- 32504797
- ISSN
- 0939-6411
- eISSN
- 1873-3441
- Number of pages
- 13
- Grant note
- Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, NY
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984365898502771
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